{"id":"W1988395319","doi":"10.1126/science.288.5463.154","title":"Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity","year":2000,"lang":"en","type":"article","venue":"Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":880,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Heterotrimeric G protein; Somatostatin; Somatostatin receptor; D1-like receptor; D2-like receptor; Somatostatin receptor 3; Somatostatin receptor 1; Receptor; Dopamine; Dopamine receptor; G protein-coupled receptor; Crosstalk; Chemistry; Dopamine receptor D2; Neurotransmitter receptor; Cell biology; G protein; Neurotransmitter; Somatostatin receptor 2; Biology; Neuroscience; Biochemistry; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000150545,0.00005074518,0.00005403464,0.00002407969,0.000092567,0.00001292631,0.00005298039,0.00002192033,0.00005323242],"category_scores_gemma":[0.00001438043,0.00004006662,0.0000148074,0.00008452639,0.0001370002,0.00001822984,0.00001110586,0.00001554767,6.246858e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005675489,"about_ca_system_score_gemma":0.00003876358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002641956,"about_ca_topic_score_gemma":0.000003938876,"domain_scores_codex":[0.9995497,0.000006542215,0.0000664328,0.0001579932,0.0001091627,0.0001101611],"domain_scores_gemma":[0.9997815,0.000006014652,0.00004310214,0.0000726673,0.00006116029,0.00003556255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009670656,0.000008932486,0.00002553975,0.000009086984,0.000001907651,1.441119e-8,0.00004015291,0.0001132793,0.9803023,0.00002300581,0.00001123945,0.01936782],"study_design_scores_gemma":[0.000251158,0.0003303863,0.0003002116,0.000007703416,0.000002348914,0.000003449622,0.00005370972,0.0004630172,0.9977352,0.00003717362,0.000758679,0.00005694589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636939,0.00002406352,0.03594274,0.00001904833,0.00004816202,0.0001032424,0.000005013988,0.000003066017,0.000160762],"genre_scores_gemma":[0.9965635,0.00002565416,0.003186248,0.00002171531,0.00002273142,0.00001175954,0.00000871756,0.000003329387,0.0001563395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03286961,"threshold_uncertainty_score":0.1633869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203360131617246,"score_gpt":0.2268458227555155,"score_spread":0.2186424626238983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}