{"id":"W1988395319","doi":"10.1126/science.288.5463.154","title":"Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity","year":2000,"lang":"en","type":"article","venue":"Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":880,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Heterotrimeric G protein; Somatostatin; Somatostatin receptor; D1-like receptor; D2-like receptor; Somatostatin receptor 3; Somatostatin receptor 1; Receptor; Dopamine; Dopamine receptor; G protein-coupled receptor; Crosstalk; Chemistry; Dopamine receptor D2; Neurotransmitter receptor; Cell biology; G protein; Neurotransmitter; Somatostatin receptor 2; Biology; Neuroscience; Biochemistry; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438158,0.0002002648,0.0001882497,0.0001427919,0.0001310306,0.00028579,0.0001473099,0.0003447409,0.0009394067],"category_scores_gemma":[0.0001090338,0.0001294875,0.0002467017,0.00007259337,0.0001420805,0.0003030326,0.0002531163,0.0002899689,0.0005853582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887051,"about_ca_system_score_gemma":0.00006605964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009580961,"about_ca_topic_score_gemma":0.0001710032,"domain_scores_codex":[0.9998546,0.00002387866,0.000009813662,0.00004590905,0.0000318257,0.000034038],"domain_scores_gemma":[0.9999098,0.000009941072,0.00002883202,0.00001124535,0.000006291528,0.0000339425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003457196,0.00001535396,0.0001095913,0.00001110787,0.000004025344,0.00005976667,0.000007748095,0.00002415181,0.9987049,0.0002112265,0.00003801331,0.0007795015],"study_design_scores_gemma":[0.00003453499,0.0004572306,0.01864109,0.0000140117,0.00004231045,0.003819306,0.00008081143,0.00293736,0.9639781,0.000509797,0.009468424,0.00001698743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875131,0.003294997,0.006411225,0.0002122719,0.0000382316,0.0000220515,0.0000994685,0.0001096627,0.002298968],"genre_scores_gemma":[0.9913727,0.0009376603,0.004071201,0.0001701325,0.00002301808,0.00002506133,0.0002858118,0.00001858145,0.003095854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009394067,"threshold_uncertainty_score":0.003142595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008203360131617246,"score_gpt":0.2268458227555155,"score_spread":0.2186424626238983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}