{"id":"W1988419855","doi":"10.1073/pnas.98.4.1859","title":"p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking <i>tsg101</i>","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"TSG101; Biology; Cell biology; Ubiquitin ligase; Mutant; Molecular biology; Ubiquitin; Cancer research; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468649,0.001016243,0.0002779143,0.0007733676,0.0002296238,0.0004523655,0.000400503,0.0008038683,0.002517088],"category_scores_gemma":[0.0001483688,0.0004120678,0.0004168647,0.0002552387,0.0005404835,0.0001923879,0.0002796801,0.001224919,0.00106399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004145611,"about_ca_system_score_gemma":0.0002866261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152301,"about_ca_topic_score_gemma":0.001542686,"domain_scores_codex":[0.9997624,0.00002892975,0.00004024892,0.00005382255,0.00007067139,0.00004394436],"domain_scores_gemma":[0.999587,0.00006349677,0.0001535102,0.00003329899,0.00001730197,0.0001454055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005638584,0.00001770687,0.0001204305,0.00001260414,0.000004655147,0.000176618,0.00000926698,0.0000369957,0.9991757,0.00008514203,0.0000278527,0.0002766566],"study_design_scores_gemma":[0.00002828707,0.0002460933,0.006633122,0.00001151606,0.00001981829,0.001304231,0.00003002239,0.0008363656,0.9888755,0.00007041843,0.001934954,0.000009751363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888949,0.0009369215,0.004343134,0.0002203264,0.00006474175,0.00005116169,0.002313885,0.0003968793,0.002778111],"genre_scores_gemma":[0.9800218,0.0007642012,0.002933366,0.0001131323,0.00001911205,0.0001182278,0.003266977,0.0002404906,0.01252268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002517088,"threshold_uncertainty_score":0.008420467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04825794617157288,"score_gpt":0.32321671949311,"score_spread":0.2749587733215371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}