{"id":"W1988424082","doi":"10.1021/jm049458s","title":"Synthesis of (±)-2-<i>O</i>-[4‘-(<i>N</i>-9‘ ‘-Purinyl)butyl] <i>myo</i>-Inositol 1,4,5-Tris(phosphate), a Potent Full Agonist at the <scp>d</scp>-<i>myo</i>-Inositol 1,4,5-Tris(phosphate) Receptor","year":2005,"lang":"he","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Inositol; Tris; Orthoester; Stereochemistry; Inositol phosphate; Potency; Phosphate; Agonist; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588661,0.000433327,0.0003947833,0.0002053945,0.0002322721,0.0002436009,0.0004818348,0.0003270367,0.005277555],"category_scores_gemma":[0.0001364064,0.0002454387,0.0002830199,0.0002646291,0.0001300901,0.0003497806,0.0002681579,0.0005371384,0.002960009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666271,"about_ca_system_score_gemma":0.0008629226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008946647,"about_ca_topic_score_gemma":0.001151924,"domain_scores_codex":[0.9999235,0.000007466141,0.000008462667,0.00001959816,0.00001432202,0.00002665639],"domain_scores_gemma":[0.9999315,0.000006717636,0.00001272568,0.000009574357,0.00001418278,0.00002531904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002054324,0.00005360219,0.00004858384,0.0001763191,0.00001097172,0.0002550622,0.00004445621,0.0004797569,0.9900298,0.00119377,0.0003359281,0.007166271],"study_design_scores_gemma":[0.0001714609,0.0009183537,0.0007567854,0.00001497526,0.00003466971,0.0004872853,0.00003107228,0.0007989143,0.9669535,0.0002406663,0.02956345,0.00002886832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8750882,0.005200183,0.0736077,0.0005530228,0.0004765675,0.001198128,0.007568772,0.001049201,0.03525829],"genre_scores_gemma":[0.9182028,0.004285734,0.0427923,0.0002049972,0.00007703998,0.000548935,0.00583627,0.0001465292,0.02790532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005277555,"threshold_uncertainty_score":0.01765513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006459846774531173,"score_gpt":0.2267880274234529,"score_spread":0.2203281806489217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}