{"id":"W1988424082","doi":"10.1021/jm049458s","title":"Synthesis of (±)-2-<i>O</i>-[4‘-(<i>N</i>-9‘ ‘-Purinyl)butyl] <i>myo</i>-Inositol 1,4,5-Tris(phosphate), a Potent Full Agonist at the <scp>d</scp>-<i>myo</i>-Inositol 1,4,5-Tris(phosphate) Receptor","year":2005,"lang":"he","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Inositol; Tris; Orthoester; Stereochemistry; Inositol phosphate; Potency; Phosphate; Agonist; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003914185,0.001714973,0.002751602,0.0002219272,0.0008200213,0.0002287574,0.00274175,0.001618133,0.0006490864],"category_scores_gemma":[0.003129697,0.001345408,0.002404067,0.0008206462,0.001926178,0.00008004455,0.0009169591,0.00209629,0.0002095996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005467276,"about_ca_system_score_gemma":0.001388696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001283855,"about_ca_topic_score_gemma":0.00003069439,"domain_scores_codex":[0.9884817,0.0006796782,0.004374135,0.001464535,0.003007231,0.001992746],"domain_scores_gemma":[0.9884306,0.001295805,0.005013899,0.001974788,0.001714166,0.001570732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001578023,0.001095187,0.001345991,0.000937699,0.001524046,0.0002342118,0.0005512413,0.0002541931,0.8064213,0.00001011811,0.1782643,0.007783677],"study_design_scores_gemma":[0.002987574,0.0006196637,0.0002069491,0.001024309,0.001728898,0.001952217,0.00153735,0.000067499,0.6538543,0.00001454503,0.3355495,0.0004572492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8536966,0.1343963,0.0002309774,0.006179461,0.002534788,0.0006403686,0.0004636296,0.00004504994,0.001812788],"genre_scores_gemma":[0.9528539,0.02705379,0.001190162,0.001364884,0.01026018,0.00004790431,0.000169661,0.000281888,0.006777688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1572852,"threshold_uncertainty_score":0.999678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006459846774531173,"score_gpt":0.2267880274234529,"score_spread":0.2203281806489217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}