{"id":"W1988463445","doi":"10.1007/s00228-002-0487-9","title":"Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression","year":2002,"lang":"en","type":"article","venue":"European Journal of Clinical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Medical Research Council Canada","keywords":"CYP3A4; Chemistry; Microsome; Population; Internal medicine; Biology; Molecular biology; Endocrinology; Enzyme; Cytochrome P450; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004164154,0.0003275814,0.0009293463,0.0002410361,0.000138372,0.00001943331,0.0005464738,0.0002663321,0.00111295],"category_scores_gemma":[0.0004626871,0.0003015332,0.0002417134,0.0002194503,0.00038109,0.0002099617,0.0002469987,0.001803421,0.00003551768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004278137,"about_ca_system_score_gemma":0.00004818615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000010699,"about_ca_topic_score_gemma":0.000002481851,"domain_scores_codex":[0.9910885,0.004687551,0.003018628,0.0004037124,0.0003191273,0.000482492],"domain_scores_gemma":[0.9968587,0.0006203893,0.00156013,0.0001594647,0.0003032332,0.0004980575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000917023,0.00181922,0.01756851,0.00005540013,0.0002721572,0.0003427212,0.0005584985,0.008721365,0.9490127,0.0000281658,0.001792031,0.01891218],"study_design_scores_gemma":[0.02173271,0.001770568,0.031432,0.0001899215,0.001063164,0.00008371935,0.00009066975,0.1439941,0.7838001,0.0007954453,0.01429991,0.0007476299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891904,0.004932997,0.002363812,0.000623274,0.001875028,0.0003735756,0.0001025775,0.00002040432,0.0005179498],"genre_scores_gemma":[0.9928846,0.003361884,0.0009602997,0.0008599314,0.001795779,0.000006803132,0.00004482852,0.00004479324,0.00004111113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1652126,"threshold_uncertainty_score":0.9999437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1714080220913108,"score_gpt":0.4408356935308331,"score_spread":0.2694276714395223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}