{"id":"W1988482775","doi":"10.1371/journal.pone.0096238","title":"Hyper-Activation of Notch3 Amplifies the Proliferative Potential of Rhabdomyosarcoma Cells","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Cancer Institute; Associazione Italiana per la Ricerca sul Cancro; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute","keywords":"PAX3; HES1; Alveolar rhabdomyosarcoma; Myogenesis; Rhabdomyosarcoma; Cell growth; Notch signaling pathway; Embryonal rhabdomyosarcoma; Cell biology; FOXO1; Biology; Cancer research; Cellular differentiation; Cell culture; Gene knockdown; Myocyte; Signal transduction; Transcription factor; Pathology; Medicine; Protein kinase B; Sarcoma; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001028407,0.0001884029,0.0001978483,0.0002004776,0.00009163668,0.000214332,0.0001056511,0.0001921141,0.0018621],"category_scores_gemma":[0.00008062494,0.00009694793,0.0002519399,0.000130245,0.0001592872,0.0001045386,0.0001798242,0.0004869665,0.0004720973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001665116,"about_ca_system_score_gemma":0.0001586342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007355178,"about_ca_topic_score_gemma":0.001155178,"domain_scores_codex":[0.9998425,0.00001991216,0.00001940617,0.00002282762,0.00005617455,0.00003911792],"domain_scores_gemma":[0.9999142,0.00001956662,0.00001547868,0.0000140574,0.000009185975,0.00002756288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006330544,0.00002091444,0.0001787209,0.00002209812,0.0000031015,0.00005207493,0.00001536764,0.00002477987,0.9988539,0.00004862354,0.00005139428,0.0006656297],"study_design_scores_gemma":[0.00001407194,0.000281645,0.01162015,0.000007810479,0.00001623473,0.0003086097,0.00007647662,0.0005844297,0.9835203,0.00004397467,0.003521701,0.000004639849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956678,0.0009001968,0.0007910348,0.00007187821,0.00002160066,0.00001615917,0.0004031151,0.00005533998,0.002072841],"genre_scores_gemma":[0.9949898,0.0005050955,0.0006369297,0.00006511762,0.000006641445,0.0000308561,0.0006656594,0.00001285234,0.003087056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018621,"threshold_uncertainty_score":0.006229401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03749029181417744,"score_gpt":0.2372074476394361,"score_spread":0.1997171558252586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}