{"id":"W1988486780","doi":"10.1038/cgt.2011.18","title":"Adjuvant effect of HER-2/neu-specific adenoviral vector stimulating CD8+ T and natural killer cell responses on anti-HER-2/neu antibody therapy for well-established breast tumors in HER-2/neu transgenic mice","year":2011,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"","keywords":"Cytotoxic T cell; Immunology; CTL*; Immunotherapy; CD8; HER2/neu; Cancer research; Antibody; Immune system; Antigen; Adjuvant; Biology; Medicine; Cancer; Breast cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001325146,0.0009095992,0.001690057,0.0006831273,0.0002008748,0.0000767948,0.000557054,0.000344268,0.001863065],"category_scores_gemma":[0.00003476853,0.0007251887,0.0005038388,0.0009195492,0.000427259,0.0002656397,0.00005263722,0.0009104548,0.00001191108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389539,"about_ca_system_score_gemma":0.0004000842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007867441,"about_ca_topic_score_gemma":0.00008451167,"domain_scores_codex":[0.9948064,0.0007478004,0.001002984,0.001314389,0.0008580281,0.001270371],"domain_scores_gemma":[0.9971024,0.0009296815,0.0003371662,0.00099764,0.0002779406,0.0003551158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0619597,0.0006213972,0.03645707,0.000271249,0.0002853265,0.00006014385,0.002760825,0.00007539782,0.8510233,0.000008261055,0.0001989018,0.04627849],"study_design_scores_gemma":[0.02834847,0.008936861,0.240253,0.0005185017,0.00006404683,0.00008531945,0.0002206962,0.000407743,0.7173641,0.00002488715,0.002952853,0.0008235402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669502,0.02711045,0.00003410466,0.0003364462,0.000993202,0.0040532,0.0001361235,0.0001192253,0.0002670122],"genre_scores_gemma":[0.9834605,0.01272002,0.0002321584,0.0004012843,0.0006907381,0.0003394252,0.00008293936,0.0003029122,0.001770062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2037959,"threshold_uncertainty_score":0.9995199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03215954182566027,"score_gpt":0.3251027456786804,"score_spread":0.2929432038530201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}