{"id":"W1988508668","doi":"10.4161/cc.9.7.11254","title":"Novel combination of Celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells","year":2010,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"MG132; Cancer research; Biology; Apoptosis; Proteasome inhibitor; Programmed cell death; Gene knockdown; Unfolded protein response; Cancer cell; Proteasome; Lactacystin; Cell growth; Cell biology; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148486,0.0001253012,0.0001478636,0.00005126962,0.00005446925,0.00001938876,0.00005947684,0.00008749314,0.000003924735],"category_scores_gemma":[0.00004744891,0.0001175437,0.0000204383,0.0000565828,0.0001082738,0.000008713924,0.00006886265,0.0001229395,7.431466e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004044946,"about_ca_system_score_gemma":0.00002901454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004589476,"about_ca_topic_score_gemma":0.00001300204,"domain_scores_codex":[0.9993316,0.00003104452,0.0001635566,0.0002574117,0.00007079924,0.0001455753],"domain_scores_gemma":[0.9996617,0.00002584626,0.00009053967,0.0001192435,0.00004981127,0.00005285484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002676774,0.0001996899,0.002921032,0.0002951552,0.000006268747,0.00000465122,0.0001223739,0.00001764334,0.9960988,0.0001519568,0.00006114533,0.00009448952],"study_design_scores_gemma":[0.001112642,0.0003605544,0.006339667,0.0000401521,0.00001388697,0.000006336292,0.00002573607,0.0006531073,0.9911278,0.0001214096,0.00005539933,0.0001433244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984755,0.0004737752,0.0002261616,0.0000117564,0.00005207699,0.0005675194,0.000004653106,0.000005873771,0.0001826746],"genre_scores_gemma":[0.9989904,0.00001144548,0.0006815945,0.00002688827,0.00008368353,0.00004278828,0.00001814389,0.00001583627,0.0001292022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004971043,"threshold_uncertainty_score":0.4793293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004155221586874642,"score_gpt":0.2087663772393137,"score_spread":0.2046111556524391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}