{"id":"W1988547152","doi":"10.1016/j.bmc.2005.08.053","title":"Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Leptosphaeria maculans; Detoxification (alternative medicine); Chemistry; Fungus; Isocoumarins; Antifungal; Biochemistry; Stereochemistry; Microbiology; Botany; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004557202,0.0001781422,0.0002606659,0.00002414311,0.00004361307,0.000008657607,0.0002100008,0.0001672218,0.00004816329],"category_scores_gemma":[0.0001605102,0.0001276582,0.0000635172,0.0001102966,0.0001846672,0.000008499679,0.00004810512,0.0001133295,6.140768e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001452611,"about_ca_system_score_gemma":0.0000983616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003249534,"about_ca_topic_score_gemma":0.00001388703,"domain_scores_codex":[0.9989452,0.00008217223,0.0003071355,0.0002668577,0.0002095195,0.0001891498],"domain_scores_gemma":[0.9993209,0.00009878416,0.0002129571,0.0002803512,0.00003982597,0.00004719523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001440117,0.0001541498,0.001976591,0.0001111062,0.00002847061,0.000002034966,0.0001284892,0.000002930053,0.9918348,0.000005952855,0.000247186,0.005364299],"study_design_scores_gemma":[0.000277729,0.00006705208,0.0121547,0.00008296483,0.0000454114,0.00004554266,0.0003145359,0.00005454827,0.9862364,0.000008369557,0.0005782752,0.0001344783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996602,0.002378544,0.0003101305,0.0003029605,0.00003749457,0.000129206,0.00006179137,0.000005174481,0.0001727045],"genre_scores_gemma":[0.9989349,0.0004494429,0.0001809227,0.0000400881,0.0003098272,0.00001362985,0.00002492494,0.00001468014,0.0000315365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01017811,"threshold_uncertainty_score":0.5205749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799669931148698,"score_gpt":0.22814426138866,"score_spread":0.210147562077173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}