{"id":"W1988547152","doi":"10.1016/j.bmc.2005.08.053","title":"Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Leptosphaeria maculans; Detoxification (alternative medicine); Chemistry; Fungus; Isocoumarins; Antifungal; Biochemistry; Stereochemistry; Microbiology; Botany; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836008,0.0004510367,0.0003128886,0.0002813498,0.0001871011,0.0003258522,0.0003570367,0.0002277074,0.0007513443],"category_scores_gemma":[0.000118107,0.0002206377,0.0002486401,0.0001961643,0.0001578045,0.000171532,0.0001248648,0.0003526882,0.0002174492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000411892,"about_ca_system_score_gemma":0.0003100531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009057895,"about_ca_topic_score_gemma":0.002186514,"domain_scores_codex":[0.9999263,0.00001174709,0.000007398868,0.00001514245,0.00001937429,0.00001992926],"domain_scores_gemma":[0.9999387,0.000008806775,0.00002453572,0.00000518672,0.000009341697,0.00001342208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002487057,0.00008167553,0.0001929866,0.0001338571,0.00002168489,0.0001019588,0.00003929485,0.00130777,0.9881337,0.0004087587,0.0001496362,0.00918002],"study_design_scores_gemma":[0.0001155334,0.0007705617,0.001112589,0.00001024299,0.00005569206,0.0002098376,0.00001734096,0.001246982,0.9904213,0.00006297475,0.005966178,0.0000106406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735253,0.008770304,0.01205122,0.0002315219,0.0000518579,0.0002448612,0.0007044778,0.0002384358,0.004182002],"genre_scores_gemma":[0.9852395,0.005757943,0.004973619,0.00007189937,0.00001544924,0.00008339224,0.000803764,0.00002526354,0.003029197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009057895,"threshold_uncertainty_score":0.002988517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799669931148698,"score_gpt":0.22814426138866,"score_spread":0.210147562077173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}