{"id":"W1988565419","doi":"10.1074/jbc.m003107200","title":"Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":339,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Transactivation; Transcription factor; Protein tertiary structure; Chemistry; Transcription (linguistics); Protein structure; DNA-binding domain; Protein domain; Biology; Cell biology; Computational biology; Biophysics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002468539,0.0001111381,0.0002577276,0.00002631436,0.00003204179,0.000005807193,0.0001526512,0.0001861975,0.001228947],"category_scores_gemma":[0.0000289451,0.00006366046,0.0001602769,0.0001308142,0.0001567746,0.00003414034,0.000006353719,0.0004892238,4.77507e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111251,"about_ca_system_score_gemma":0.00006613114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003303018,"about_ca_topic_score_gemma":6.422452e-7,"domain_scores_codex":[0.9988254,0.00005259024,0.0005436448,0.000109352,0.0003268084,0.0001422487],"domain_scores_gemma":[0.9995221,0.00002819742,0.0002127712,0.0001089436,0.00006903097,0.00005893963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000568481,0.00007056441,0.001492909,0.0000262113,0.00004474942,0.00004204906,0.00011536,0.00007082713,0.9941634,0.00007150761,0.0000573537,0.003276602],"study_design_scores_gemma":[0.004989128,0.0007872323,0.14176,0.0001581051,0.00005894512,0.00110985,0.0005472152,0.00005292187,0.8448086,0.004120893,0.001453579,0.0001535356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982572,0.0001230276,0.000131738,0.0005482579,0.00002687906,0.00009310202,0.000009726991,0.000004166649,0.0008058975],"genre_scores_gemma":[0.9992126,0.00001768616,0.0004031445,0.000183256,0.0001226191,0.000001592758,0.00003449521,0.000005037113,0.00001962998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1493548,"threshold_uncertainty_score":0.999684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01941308011156792,"score_gpt":0.2738507396739198,"score_spread":0.2544376595623518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}