{"id":"W1988591365","doi":"10.4161/cc.21754","title":"Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan","year":2012,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Concordia University","keywords":"Longevity; Biology; Yeast; Lithocholic acid; Saccharomyces cerevisiae; Ageing; Cell biology; Genetics; Biochemistry; Bile acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009085367,0.0002019566,0.000238338,0.0001931631,0.0000992565,0.0002157255,0.0001494405,0.0001570352,0.001072022],"category_scores_gemma":[0.0001182808,0.0000780703,0.0001562721,0.0001244592,0.0001210155,0.0001572102,0.0002110492,0.000326223,0.0001339461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001531091,"about_ca_system_score_gemma":0.0001989565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007106419,"about_ca_topic_score_gemma":0.001093537,"domain_scores_codex":[0.9999307,0.00001082775,0.00001206972,0.00001910459,0.00001448206,0.00001289794],"domain_scores_gemma":[0.9998061,0.00002815844,0.00005533798,0.0000270596,0.00003091517,0.00005253835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002579375,0.00003455044,0.0003578888,0.00003565872,0.000005807308,0.0000247536,0.00001495859,0.00005322247,0.9974039,0.00004316874,0.00001253809,0.001755596],"study_design_scores_gemma":[0.00001547203,0.001374508,0.01013957,0.00001109503,0.00002824358,0.00008924494,0.00004547977,0.0004949553,0.9859288,0.00006282987,0.001803295,0.000006484103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966716,0.001320172,0.0009755366,0.00005617917,0.00002056143,0.00001081564,0.0002177248,0.00005821599,0.0006693036],"genre_scores_gemma":[0.996106,0.0008495288,0.001384242,0.00005513161,0.000008144067,0.00001722363,0.000351671,0.00001558485,0.001212384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072022,"threshold_uncertainty_score":0.003586233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246696136561452,"score_gpt":0.2523690183879279,"score_spread":0.2399020570223134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}