{"id":"W1988607416","doi":"10.1038/onc.2015.75","title":"Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability","year":2015,"lang":"en","type":"article","venue":"Oncogene","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC","keywords":"Telomere; Biology; Telomerase; Telomerase reverse transcriptase; Chromosome instability; DNA damage; Genome instability; Molecular biology; DNA repair; Phenotype; Cell division; Cell cycle; Chromosome; Genetics; DNA; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004695087,0.0004251647,0.0006483183,0.0002116541,0.0002738778,0.00004874135,0.0001900883,0.0001566234,0.0001045579],"category_scores_gemma":[0.0001511186,0.0003826731,0.0001278527,0.0004393402,0.0001979975,0.000306647,0.00005475379,0.0002984592,0.00003402189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157191,"about_ca_system_score_gemma":0.0003033919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004028006,"about_ca_topic_score_gemma":0.00009744866,"domain_scores_codex":[0.997293,0.0001694638,0.0005586682,0.000772801,0.0005996939,0.0006064061],"domain_scores_gemma":[0.9977725,0.00003913119,0.00009890975,0.0006319141,0.0001860432,0.001271567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007210515,0.0006434597,0.006282591,0.0003654354,0.00002565905,0.000438403,0.002615804,0.00001634807,0.9756525,0.000005037405,0.002074478,0.01115929],"study_design_scores_gemma":[0.005621418,0.0006884953,0.008249492,0.0007451095,0.00008224948,0.00009305524,0.0009650944,0.0001183919,0.9508275,0.00002880545,0.0319981,0.0005822596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955932,0.0004901128,0.0001491978,0.0006570781,0.0002021705,0.001753901,0.0001127998,0.0001858475,0.0008556668],"genre_scores_gemma":[0.9947987,0.0001260656,0.002195358,0.002039157,0.0002489323,0.000127625,0.00009307389,0.00005879977,0.0003122457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02992362,"threshold_uncertainty_score":0.9998625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215267063170156,"score_gpt":0.2917230380519025,"score_spread":0.249570367420201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}