{"id":"W1988630698","doi":"10.1021/ac200534t","title":"Continuous Flow Immobilized Enzyme Reactor–Tandem Mass Spectrometry for Screening of AChE Inhibitors in Complex Mixtures","year":2011,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Chemistry; Chromatography; Substrate (aquarium); Immobilized enzyme; Acetylcholinesterase; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001683589,0.001890752,0.001397774,0.001441571,0.0005436788,0.0007960037,0.001772363,0.001828247,0.001296139],"category_scores_gemma":[0.001144459,0.000824523,0.0006621933,0.0008905402,0.0005416625,0.0006386318,0.0006832096,0.00200984,0.001453387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007300391,"about_ca_system_score_gemma":0.0007490299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009136956,"about_ca_topic_score_gemma":0.001765606,"domain_scores_codex":[0.9986336,0.000274141,0.00008121109,0.000344914,0.000579988,0.00008617612],"domain_scores_gemma":[0.999482,0.0002142944,0.00009590039,0.00004677548,0.0001088779,0.00005222792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075697,0.00007772116,0.0001703681,0.0001254031,0.00004142374,0.0000458519,0.0000114678,0.0001597248,0.9909577,0.0001581989,0.0002393218,0.007905087],"study_design_scores_gemma":[0.00006493742,0.0004570459,0.001347121,0.00001795383,0.00006952021,0.0006677248,0.00001497552,0.01233352,0.9790646,0.0001982079,0.00571198,0.00005233093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1743094,0.01926359,0.7868178,0.0006226684,0.0005352718,0.001468816,0.002226121,0.01011798,0.004638209],"genre_scores_gemma":[0.3026539,0.01170907,0.6711079,0.001082302,0.0002060853,0.002554485,0.002671866,0.0002842168,0.007730332],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001890752,"threshold_uncertainty_score":0.008903801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06173510039531576,"score_gpt":0.3069381448518511,"score_spread":0.2452030444565353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}