{"id":"W1988642118","doi":"10.1124/jpet.112.192344","title":"Differential Role of Organic Anion-Transporting Polypeptides in Estrone-3-Sulphate Uptake by Breast Epithelial Cells and Breast Cancer Cells","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Estrone sulfate; Organic anion-transporting polypeptide; Breast cancer; Solute carrier family; Cancer research; Estrone; Cancer cell; Abcg2; Cancer; Chemistry; Internal medicine; Hormone; Endocrinology; Biology; Pharmacology; Medicine; Transporter; Biochemistry; Gene; ATP-binding cassette transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777699,0.000163322,0.0002561481,0.0001726242,0.0002506148,0.0005218019,0.0001172096,0.0002957943,0.0009810579],"category_scores_gemma":[0.0001892921,0.0001542204,0.0002662267,0.0002919972,0.0002237666,0.0005103163,0.0002287504,0.0003104299,0.0003632739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131754,"about_ca_system_score_gemma":0.0002321008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332094,"about_ca_topic_score_gemma":0.001028752,"domain_scores_codex":[0.9998166,0.0000431409,0.00002098821,0.0000250316,0.00004218267,0.00005204073],"domain_scores_gemma":[0.9998159,0.00005904704,0.00001817111,0.00002129356,0.00005446609,0.00003123822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004099706,0.00001277975,0.0007095755,0.00004454859,0.000005233629,0.00009083822,0.0001185933,0.00002324431,0.9976125,0.0001250353,0.00001675288,0.0008310063],"study_design_scores_gemma":[0.00002682808,0.0004167611,0.05005385,0.0000135667,0.00004674735,0.0006514334,0.0007362868,0.0007060397,0.9420578,0.00011725,0.005157973,0.00001556378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960524,0.001792991,0.0005408614,0.00009274174,0.00001814752,0.000006815036,0.0001822855,0.00001374095,0.001300121],"genre_scores_gemma":[0.995867,0.0008514783,0.0004216985,0.00004044286,0.000008165393,0.00001278086,0.0004264909,0.000009598063,0.002362212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332094,"threshold_uncertainty_score":0.003282011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008957992977361632,"score_gpt":0.2839886529164597,"score_spread":0.2750306599390981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}