{"id":"W1988654486","doi":"10.1074/jbc.m602700200","title":"β-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Endochondral ossification; Chondrogenesis; Wnt signaling pathway; Cell biology; Bone morphogenetic protein; Bone morphogenetic protein 7; Chemistry; Bone morphogenetic protein 2; Mesenchymal stem cell; Bone morphogenetic protein 5; Catenin; Biology; Signal transduction; Cartilage; Anatomy; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484494,0.000494575,0.0002407448,0.0003327197,0.0002004646,0.0004448814,0.0001894716,0.000332097,0.001762669],"category_scores_gemma":[0.000113102,0.00030652,0.0002757291,0.0001616154,0.0002346169,0.0002687745,0.0002804673,0.0005972674,0.000704557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004487023,"about_ca_system_score_gemma":0.0004891495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005824904,"about_ca_topic_score_gemma":0.001075152,"domain_scores_codex":[0.9998214,0.00001690352,0.00002154336,0.00003719148,0.00007220263,0.00003073485],"domain_scores_gemma":[0.9998969,0.00001008411,0.00003147083,0.000009830357,0.00001159086,0.00004020837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003966864,0.0000134891,0.0001016761,0.00003383752,0.00000271186,0.0000448744,0.000003954967,0.00002591418,0.9989642,0.0001402512,0.00002576295,0.0006036694],"study_design_scores_gemma":[0.00002631554,0.000111399,0.008043182,0.00001304877,0.00001809428,0.0005419438,0.00001542781,0.0005622547,0.9814277,0.0001057237,0.009130052,0.000004787793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781744,0.00907801,0.005143712,0.0002270881,0.000141554,0.00006533344,0.0009941062,0.0002318132,0.005943863],"genre_scores_gemma":[0.985336,0.002945257,0.001961346,0.00008380255,0.00001587703,0.0000574874,0.001583998,0.00003501295,0.007981205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001762669,"threshold_uncertainty_score":0.005896688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253756975125978,"score_gpt":0.2425550656428384,"score_spread":0.2200174958915786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}