{"id":"W1988720233","doi":"10.1074/jbc.m312500200","title":"Differential Amplification of Intron-containing Transcripts Reveals Long Term Potentiation-associated Up-regulation of Specific Pde10A Phosphodiesterase Splice Variants","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"","keywords":"Biology; Differential display; PDE10A; Gene; Phosphodiesterase; Molecular biology; Intron; Messenger RNA; Gene expression; Long-term potentiation; Genetics; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002596619,0.0001762312,0.0003556682,0.00004116363,0.0000603271,0.00001342223,0.0001763361,0.0003123842,0.00009983587],"category_scores_gemma":[0.0001526362,0.0001419636,0.0002052108,0.0001200617,0.000119097,0.00001883995,0.00003129267,0.0001463088,6.326778e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006854538,"about_ca_system_score_gemma":0.00007219126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005353711,"about_ca_topic_score_gemma":0.000001787182,"domain_scores_codex":[0.9984599,0.00006111098,0.000866288,0.000220773,0.0002214514,0.0001704221],"domain_scores_gemma":[0.998168,0.00002640592,0.001114512,0.0001931323,0.000410207,0.00008776723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000745649,0.0002436255,0.01493984,0.0000429997,0.0001186936,0.000001692862,0.00008118284,0.0002591955,0.9826706,0.00002079611,0.00004224349,0.0008334445],"study_design_scores_gemma":[0.001409337,0.0002723366,0.3322014,0.00009428299,0.00003629782,0.00002683209,0.00004867514,0.00000813656,0.6656339,0.0001319075,0.0000313583,0.0001054859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830895,0.0004914668,0.01585264,0.00007616042,0.0002915538,0.0001075153,0.0000281442,0.000006317113,0.00005667766],"genre_scores_gemma":[0.9987823,0.0003111315,0.0002782511,0.00002496517,0.0002254548,0.000002830975,0.0002878112,0.000011085,0.00007617006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3172616,"threshold_uncertainty_score":0.5789106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02016051326465288,"score_gpt":0.2430010538972157,"score_spread":0.2228405406325629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}