{"id":"W1988753673","doi":"10.1016/j.jmb.2008.08.027","title":"CRP Binding and Transcription Activation at CRP-S Sites","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Promoter; Binding site; Consensus sequence; Biology; Haemophilus influenzae; DNA binding site; Base pair; Transcription (linguistics); Molecular biology; DNA; Conserved sequence; DNA-binding protein; Transcription factor; Genetics; Gene; Base sequence; Gene expression; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000149096,0.0001296047,0.0001912507,0.0001157902,0.00008826006,0.000007432454,0.0001294289,0.0003628232,0.00001585481],"category_scores_gemma":[0.00007075129,0.0001106823,0.00009816173,0.00007105509,0.0001711302,0.000004150291,0.00007271382,0.0001256327,0.000002525659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001811404,"about_ca_system_score_gemma":0.00004004605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002710545,"about_ca_topic_score_gemma":0.00000353535,"domain_scores_codex":[0.9991962,0.00007842402,0.0002892217,0.0001897606,0.00006561683,0.000180797],"domain_scores_gemma":[0.9994541,0.000007645494,0.0002259477,0.0001378619,0.000108523,0.00006585299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536108,0.00002994321,0.002729342,0.000005366561,0.00006110224,0.00001482647,0.00002257076,0.000004667276,0.9952239,0.00008953077,0.0002271253,0.001437954],"study_design_scores_gemma":[0.0006143715,0.001009079,0.002958233,0.000007725834,0.0000204593,0.0007672418,0.00001313495,0.000004681833,0.9773067,0.000174295,0.01699892,0.0001251502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948065,0.001104337,0.003205698,0.0005563347,0.0001746828,0.00006683278,0.000006356417,0.000004729569,0.00007458465],"genre_scores_gemma":[0.9962174,0.001388382,0.001857295,0.0002241815,0.0001750664,0.000001557681,0.00004169585,0.00001405995,0.00008038246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01791726,"threshold_uncertainty_score":0.4513495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293047233406559,"score_gpt":0.2417093628116425,"score_spread":0.228778890477577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}