{"id":"W1988787754","doi":"10.1016/j.addr.2008.12.014","title":"Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy","year":2009,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada); University of British Columbia; Centre for Drug Research and Development","funders":"","keywords":"CpG Oligodeoxynucleotide; Biodistribution; Immune system; Immunotherapy; In vivo; Oligonucleotide; Drug delivery; Pharmacology; Cancer research; Medicine; Chemistry; Immunology; Biology; DNA methylation; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006100779,0.001124113,0.003247126,0.0002549616,0.0001235285,0.00004311319,0.001270136,0.0004640407,0.000104114],"category_scores_gemma":[0.0001084243,0.0009253073,0.002169184,0.0004389546,0.0002145403,0.00002623853,0.000176071,0.0004218801,0.0003120268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007206922,"about_ca_system_score_gemma":0.0004757844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002386775,"about_ca_topic_score_gemma":0.00002905893,"domain_scores_codex":[0.9951212,0.0006439673,0.002033563,0.00119618,0.0002974634,0.0007076037],"domain_scores_gemma":[0.9961674,0.0001442713,0.001571125,0.001682346,0.0002654916,0.0001694202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008499191,0.0001982152,0.000002127219,0.004890908,0.0002283541,0.000005268562,0.0000131774,0.00002896269,0.00674097,0.000004802027,0.001833438,0.9859688],"study_design_scores_gemma":[0.000481429,0.0004423837,0.000004160167,0.01537966,0.0007558085,0.00001374501,0.000008786536,0.000004974236,0.00795006,0.00001037038,0.9740391,0.000909459],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003735571,0.9934236,0.0001559979,0.00001275034,0.0004636127,0.001652224,0.00008855327,0.00003735899,0.0004302856],"genre_scores_gemma":[0.0004266412,0.9954547,0.001402581,0.0006459173,0.000388854,0.0002745308,0.000610163,0.0001189073,0.0006776663],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9850593,"threshold_uncertainty_score":0.9993197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03171021807210941,"score_gpt":0.3230378643818853,"score_spread":0.2913276463097758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}