{"id":"W1988790435","doi":"10.1016/j.mrgentox.2015.02.005","title":"Use of a standardized JaCVAM in vivo rat comet assay protocol to assess the genotoxicity of three coded test compounds; ampicillin trihydrate, 1,2-dimethylhydrazine dihydrochloride, and N-nitrosodimethylamine","year":2015,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Genotoxicity; Comet assay; N-Nitrosodimethylamine; 1,2-Dimethylhydrazine; In vivo; Carcinogen; Chemistry; DNA damage; Pharmacology; Toxicology; Toxicity; Medicine; Biology; DNA; Biochemistry; Genetics; Organic chemistry; Carcinogenesis; Azoxymethane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002014286,0.0002705635,0.0004768815,0.0002642587,0.0001613927,0.00004367229,0.0002321079,0.0002371964,0.00004054219],"category_scores_gemma":[0.000559469,0.0002261792,0.00007087171,0.0003673418,0.0008831054,0.00001802804,0.0004433574,0.0002042186,0.000001774921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001048827,"about_ca_system_score_gemma":0.0001347607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002308162,"about_ca_topic_score_gemma":0.0008971202,"domain_scores_codex":[0.996942,0.0008484889,0.0006594035,0.0005711156,0.0005452054,0.0004337696],"domain_scores_gemma":[0.998413,0.0006157943,0.0001956127,0.000432268,0.00009814116,0.00024515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000981906,0.000434589,0.06884412,0.00005424682,0.00006758252,0.00001829364,0.0002162196,0.002032237,0.9252264,0.000009366181,0.0001582422,0.001956764],"study_design_scores_gemma":[0.002543867,0.002564022,0.1253455,0.00001936198,0.00003494762,0.00003122781,0.0004779001,0.001412334,0.8655905,0.0001310517,0.001619087,0.0002302489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847245,0.0002158173,0.002603939,0.0001918446,0.00003961281,0.01182167,0.0003527011,0.000005519147,0.00004434795],"genre_scores_gemma":[0.9920588,0.00008901086,0.002468924,0.0001170397,0.00003702949,0.005012925,0.00005630803,0.00003006647,0.0001299448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.059636,"threshold_uncertainty_score":0.922332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08057104173110116,"score_gpt":0.3382062294737777,"score_spread":0.2576351877426766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}