{"id":"W1988790435","doi":"10.1016/j.mrgentox.2015.02.005","title":"Use of a standardized JaCVAM in vivo rat comet assay protocol to assess the genotoxicity of three coded test compounds; ampicillin trihydrate, 1,2-dimethylhydrazine dihydrochloride, and N-nitrosodimethylamine","year":2015,"lang":"en","type":"article","venue":"Mutation Research/Genetic Toxicology and Environmental Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Genotoxicity; Comet assay; N-Nitrosodimethylamine; 1,2-Dimethylhydrazine; In vivo; Carcinogen; Chemistry; DNA damage; Pharmacology; Toxicology; Toxicity; Medicine; Biology; DNA; Biochemistry; Genetics; Organic chemistry; Carcinogenesis; Azoxymethane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004935186,0.001669162,0.0009987031,0.002671486,0.001018112,0.0006029526,0.001320019,0.001094102,0.004124016],"category_scores_gemma":[0.002198678,0.0005892448,0.001050982,0.001333428,0.0008456962,0.0005742003,0.000799138,0.001677366,0.001191595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004454532,"about_ca_system_score_gemma":0.001782011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203996,"about_ca_topic_score_gemma":0.003643557,"domain_scores_codex":[0.9952196,0.001219845,0.0006587695,0.0009104245,0.00174106,0.0002501833],"domain_scores_gemma":[0.9945042,0.0004208754,0.0009486425,0.001157466,0.002709586,0.0002592193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003876277,0.0003807504,0.001442019,0.0003364712,0.00004871128,0.0001237449,0.0001886658,0.0002986814,0.9897927,0.000366284,0.0006131088,0.006021273],"study_design_scores_gemma":[0.00008171624,0.004864238,0.006590424,0.00005794804,0.0001672406,0.0004027642,0.0000821496,0.001238439,0.9724317,0.0001672827,0.01386169,0.00005438748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5021437,0.00206536,0.4533454,0.000371935,0.0004781669,0.02081615,0.005733485,0.002679391,0.01236635],"genre_scores_gemma":[0.3187924,0.004199974,0.6053607,0.0008189864,0.0001072381,0.02757975,0.02320952,0.0004986487,0.01943288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004935186,"threshold_uncertainty_score":0.0261001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08057104173110116,"score_gpt":0.3382062294737777,"score_spread":0.2576351877426766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}