{"id":"W1988804015","doi":"10.1021/bc0101259","title":"Synthesis and Properties of Novel Tetraalkyl Cationic Lipids","year":2002,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"","keywords":"Cationic polymerization; Chemistry; Transfection; Divalent; Steric effects; Biophysics; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000263342,0.0003072676,0.0002147149,0.0002579816,0.0002284533,0.0004182782,0.000255183,0.0003146641,0.0007173164],"category_scores_gemma":[0.0004274077,0.0001439618,0.0002183915,0.0002343317,0.00019263,0.0003837362,0.0002486221,0.0003794231,0.0004085063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004264891,"about_ca_system_score_gemma":0.0002505109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000421175,"about_ca_topic_score_gemma":0.0005648179,"domain_scores_codex":[0.9998538,0.00001914534,0.000020415,0.00002748981,0.00005966983,0.00001940376],"domain_scores_gemma":[0.9996461,0.00006717272,0.0000920671,0.00003185026,0.0001002884,0.00006245401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003811127,0.000009302376,0.00005266035,0.0000370749,0.000002069081,0.00003614164,0.00001419818,0.0001136953,0.9965506,0.0001599976,0.00002326729,0.002962923],"study_design_scores_gemma":[0.000009055033,0.0001451919,0.0002448939,0.000003932545,0.000007244669,0.0002115883,0.000007246168,0.0003757639,0.9938284,0.00005980085,0.005100571,0.000006412926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514769,0.007638349,0.036229,0.0002729524,0.00009565827,0.0001496268,0.0004343041,0.0001728507,0.003530406],"genre_scores_gemma":[0.94107,0.006553816,0.0403255,0.0002342978,0.00004891835,0.0001789209,0.00113009,0.0000909918,0.01036737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007173164,"threshold_uncertainty_score":0.003094375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02677362505277695,"score_gpt":0.2146561488603214,"score_spread":0.1878825238075445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}