{"id":"W1988804015","doi":"10.1021/bc0101259","title":"Synthesis and Properties of Novel Tetraalkyl Cationic Lipids","year":2002,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada); University of British Columbia","funders":"","keywords":"Cationic polymerization; Chemistry; Transfection; Divalent; Steric effects; Biophysics; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005101724,0.0001249954,0.0001223929,0.00001315351,0.00003972553,0.00001639665,0.0001388172,0.0001308526,0.00009221379],"category_scores_gemma":[0.00008032659,0.0001129113,0.00005303686,0.00004107899,0.0001448749,0.000004050266,0.00006678577,0.0000469322,0.000007304788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006566028,"about_ca_system_score_gemma":0.00001889515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001397189,"about_ca_topic_score_gemma":0.000001693232,"domain_scores_codex":[0.9993497,0.000006736957,0.0001781305,0.0002509317,0.00007142574,0.0001430372],"domain_scores_gemma":[0.9995334,0.000005160279,0.00006745198,0.000265583,0.0000732094,0.000055184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000160932,0.00007239085,0.0003727541,0.0001092388,0.00003677177,3.347122e-7,0.00003356947,0.00000221238,0.9975125,0.000004061261,0.000662327,0.001177753],"study_design_scores_gemma":[0.0002010262,0.000037654,0.0001352598,0.00005326557,0.00001670363,0.00001855979,0.00007294126,0.0001090281,0.9956565,0.000002645485,0.003552249,0.0001441564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942634,0.002737236,0.00002974526,0.0001126445,0.00003567015,0.00006675009,0.00002216263,0.00000910891,0.002723307],"genre_scores_gemma":[0.9968977,0.0008049102,0.0001114551,0.00005827672,0.000130204,0.00002672069,0.00001033967,0.00001294152,0.001947439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002889922,"threshold_uncertainty_score":0.4604387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02677362505277695,"score_gpt":0.2146561488603214,"score_spread":0.1878825238075445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}