{"id":"W1988805210","doi":"10.1038/nrm1960","title":"Reading protein modifications with interaction domains","year":2006,"lang":"en","type":"review","venue":"Nature Reviews Molecular Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":666,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Posttranslational modification; Proteome; Computational biology; Protein–protein interaction; Reading (process); Cell biology; Computer science; Biology; Chemistry; Bioinformatics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005277009,0.001537457,0.001694395,0.001174735,0.0003105297,0.00111287,0.001643107,0.001377235,0.002840174],"category_scores_gemma":[0.0004379904,0.0005442537,0.0003949794,0.001840812,0.0007730033,0.001360878,0.0009723948,0.001715447,0.005193883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006204327,"about_ca_system_score_gemma":0.0003220175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971857,"about_ca_topic_score_gemma":0.0006316566,"domain_scores_codex":[0.9997751,0.00002453234,0.000021576,0.00006016889,0.00008595115,0.0000327273],"domain_scores_gemma":[0.9998293,0.00006137445,0.00003871743,0.00001877321,0.00003379207,0.00001791923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001740831,0.0001020845,0.0002425178,0.005646542,0.0001037886,0.000973003,0.00005313977,0.0005862964,0.0719653,0.008421424,0.03295144,0.8787804],"study_design_scores_gemma":[0.00003191431,0.0000610118,0.0009051963,0.0003984699,0.00009295536,0.00284061,0.00002285832,0.0001829067,0.03627296,0.002896765,0.95627,0.0000242501],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001823996,0.986465,0.003392796,0.0004002392,0.001250229,0.00002686533,0.00009590952,0.0001263657,0.006418661],"genre_scores_gemma":[0.007473769,0.9787675,0.002612418,0.0006985352,0.0007029056,0.00004921237,0.0003461195,0.0000196892,0.009329836],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002840174,"threshold_uncertainty_score":0.009501278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02166225441878624,"score_gpt":0.3182832856933068,"score_spread":0.2966210312745206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}