{"id":"W1988839174","doi":"10.1016/j.vaccine.2009.12.001","title":"Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: Effects of host background and route of immunization","year":2009,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service","keywords":"Francisella tularensis; Virulence; Attenuated vaccine; Tularemia; Biology; Microbiology; Virology; Vaccination; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001758986,0.000477057,0.0002813144,0.0002576504,0.0001264196,0.0002326919,0.0003819843,0.0003821877,0.001006012],"category_scores_gemma":[0.0001679298,0.0001908823,0.0002510513,0.000126705,0.0002801266,0.0001934978,0.0001704999,0.0006952494,0.0002734259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638167,"about_ca_system_score_gemma":0.0002107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007803853,"about_ca_topic_score_gemma":0.0009403349,"domain_scores_codex":[0.9998732,0.00001871556,0.00001441743,0.000020531,0.00002944944,0.00004368805],"domain_scores_gemma":[0.9998191,0.00005406792,0.00004435828,0.00001961582,0.00002241015,0.00004050813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212039,0.00004344545,0.00006517158,0.000009134258,0.000003243873,0.0000119041,0.00000639878,0.00003659241,0.9993888,0.0000369372,0.00001154388,0.0002656586],"study_design_scores_gemma":[0.00002680427,0.0005670879,0.001444158,0.000002493721,0.00001711906,0.0001273435,0.00001409,0.0005065489,0.996775,0.00002582685,0.0004897341,0.000003757421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981517,0.0002842154,0.0009642279,0.0000476781,0.00002054321,0.00001567684,0.000201132,0.0000326912,0.0002820238],"genre_scores_gemma":[0.9958394,0.0002455852,0.001198067,0.00003949405,0.00001041262,0.00002966511,0.0006978722,0.00002651349,0.001912903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006012,"threshold_uncertainty_score":0.003365457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112833214200843,"score_gpt":0.2369840970441473,"score_spread":0.225700775624063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}