{"id":"W1988854705","doi":"10.1016/j.cbi.2013.05.006","title":"Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells","year":2013,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Cytotoxicity; Lactate dehydrogenase; Cytotoxic T cell; Toxicity; Pharmacology; Lung; Metabolite; Amiodarone; Programmed cell death; Chemistry; Apoptosis; Medicine; In vitro; Internal medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001097602,0.0002405198,0.0004044527,0.0001339078,0.0001178765,0.00006121443,0.000102542,0.0001759089,0.001614797],"category_scores_gemma":[0.00007554437,0.0001934676,0.0001066159,0.0001552956,0.000203231,0.0001724423,0.000114459,0.0007578101,0.0001091686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066139,"about_ca_system_score_gemma":0.00001565899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001588985,"about_ca_topic_score_gemma":0.000007714938,"domain_scores_codex":[0.9985998,0.0000496443,0.000461983,0.0004176349,0.0001050363,0.0003659001],"domain_scores_gemma":[0.999212,0.000175468,0.0001105032,0.0001998296,0.00008412005,0.0002180767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004254055,0.0002559734,0.02778822,0.00002795851,0.00004966323,0.00001001459,0.0001263357,0.000006579363,0.9687552,0.00005451291,0.001269041,0.001613932],"study_design_scores_gemma":[0.00207205,0.000410024,0.2443069,0.0001643575,0.00009880726,0.00009271617,0.0004808212,0.002025493,0.7453285,0.0004286637,0.004156459,0.0004352124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954873,0.0000581543,0.00029136,0.0008485609,0.0002184224,0.0004928033,0.00001982619,0.00008101841,0.002502574],"genre_scores_gemma":[0.9976893,0.0001148234,0.0005323213,0.0002934592,0.0004249707,0.00003301193,0.0001416576,0.00002262848,0.0007478367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2234268,"threshold_uncertainty_score":0.9992979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0404444209080187,"score_gpt":0.3399915763231728,"score_spread":0.2995471554151541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}