{"id":"W1988878042","doi":"10.1158/1078-0432.ccr-14-1814","title":"A Phase Ib Dose-Escalation Study of the Oral Pan-PI3K Inhibitor Buparlisib (BKM120) in Combination with the Oral MEK1/2 Inhibitor Trametinib (GSK1120212) in Patients with Selected Advanced Solid Tumors","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":326,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Trametinib; Internal medicine; Adverse effect; Stomatitis; MEK inhibitor; Rash; KRAS; Gastroenterology; Cancer; Oncology; Colorectal cancer; Kinase; MAPK/ERK pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002948979,0.0002483622,0.0004714849,0.0001329354,0.0001454113,0.00004938629,0.0005898659,0.0002151848,0.0000205595],"category_scores_gemma":[0.001219138,0.0001481422,0.00007173022,0.0013897,0.0006265257,0.00002539283,0.0002196523,0.0009693837,0.000001817092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617542,"about_ca_system_score_gemma":0.0005871722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000441523,"about_ca_topic_score_gemma":0.005898514,"domain_scores_codex":[0.9948492,0.001953189,0.0008232566,0.0007443203,0.001075173,0.000554828],"domain_scores_gemma":[0.9974903,0.0003976341,0.0003240736,0.0006993739,0.0009802897,0.0001082701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01894048,0.01067186,0.8980439,0.0000766399,0.0001524997,0.000004846996,0.0007763599,0.001605964,0.0219706,0.00001886303,0.001025322,0.04671261],"study_design_scores_gemma":[0.04570298,0.02692071,0.885449,0.0003463333,0.00004791146,7.650052e-7,0.0006387715,0.000841029,0.03856685,0.00005145777,0.001006636,0.0004275639],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972096,0.00007225874,0.00005726961,0.0004099542,0.0001786233,0.001996766,0.00002422395,0.0000113127,0.00003996909],"genre_scores_gemma":[0.9990084,0.00001644981,0.00006844161,0.00009865087,0.0001925598,0.0004439811,0.00005100282,0.00005040059,0.00007016565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04628505,"threshold_uncertainty_score":0.6041064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04835023933742931,"score_gpt":0.4285802565226542,"score_spread":0.3802300171852249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}