{"id":"W1988925392","doi":"10.1002/syn.10292","title":"PET quantification of muscarinic cholinergic receptors with [N‐<sup>11</sup>C‐methyl]‐benztropine and application to studies of propofol‐induced unconsciousness in healthy human volunteers","year":2003,"lang":"en","type":"article","venue":"Synapse","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Muscarinic acetylcholine receptor; Chemistry; Benztropine; Unconsciousness; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M4; Receptor; Endocrinology; Anesthesia; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005873697,0.0004593867,0.0004774514,0.0001944105,0.0001372547,0.0003157384,0.0002764239,0.0004697022,0.0003536947],"category_scores_gemma":[0.00144827,0.0003286761,0.0001563415,0.0001469347,0.0002476497,0.0001935167,0.0001426982,0.0001767893,0.0001529527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002015,"about_ca_system_score_gemma":0.0001593065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001793909,"about_ca_topic_score_gemma":0.002492849,"domain_scores_codex":[0.999801,0.00008018981,0.00001096189,0.00005418039,0.00004085128,0.0000128677],"domain_scores_gemma":[0.9997438,0.0001132364,0.00005876023,0.00002962714,0.00003988913,0.00001472583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005755253,0.000164032,0.0607564,0.0002818618,0.0002978581,0.0008434704,0.0003574716,0.006765283,0.83907,0.0002027481,0.000202625,0.08530299],"study_design_scores_gemma":[0.0003644856,0.008199856,0.6065215,0.0000381811,0.0006607898,0.0128738,0.0003936918,0.06229179,0.3057437,0.0004230099,0.002370403,0.0001187549],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743152,0.002321622,0.0227426,0.00005461467,0.000005758711,0.0000496614,0.00007114589,0.00006995917,0.0003693844],"genre_scores_gemma":[0.9884301,0.0008141602,0.01031815,0.00003940663,0.000009026829,0.00005596444,0.00007961224,0.00002204493,0.0002314332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793909,"threshold_uncertainty_score":0.00356698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03642044613815328,"score_gpt":0.337838432979908,"score_spread":0.3014179868417547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}