{"id":"W1988958512","doi":"10.1016/j.bcp.2013.11.015","title":"Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy","year":2013,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Cytochrome P450; Pressure overload; Arachidonic acid; Arachidonic acid metabolism; Cardiac hypertrophy; Internal medicine; Metabolism; Chemistry; Muscle hypertrophy; Endocrinology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003872341,0.0004557364,0.0006076982,0.0005485857,0.0004288864,0.0003629831,0.0002322238,0.0004767757,0.001430698],"category_scores_gemma":[0.0004875145,0.0003066413,0.0004198106,0.0003478013,0.0008269295,0.0007833898,0.000295317,0.001347798,0.0002571108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003563942,"about_ca_system_score_gemma":0.0002946474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007192138,"about_ca_topic_score_gemma":0.00097677,"domain_scores_codex":[0.9997829,0.00004392515,0.00001643772,0.00003173979,0.00004842916,0.00007663808],"domain_scores_gemma":[0.9996159,0.00006615997,0.00008106584,0.00005201987,0.00004346306,0.0001414083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01261911,0.0002777559,0.001834578,0.00004668551,0.00002933744,0.0008093437,0.0001671234,0.00009271904,0.980585,0.0001590084,0.00006921802,0.003310058],"study_design_scores_gemma":[0.0002500736,0.003859654,0.1064918,0.00001135921,0.0001328273,0.000873109,0.0003436953,0.001510572,0.8854924,0.0003541245,0.0006499939,0.00003044362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971523,0.0006496958,0.001240874,0.000104981,0.00004448089,0.00003330283,0.0001291935,0.00003485713,0.0006102384],"genre_scores_gemma":[0.9977506,0.0003284581,0.0003892045,0.0000501117,0.00005502502,0.00005162324,0.0001842767,0.000009784572,0.001180802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430698,"threshold_uncertainty_score":0.004786134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009184593089259233,"score_gpt":0.2555249219290601,"score_spread":0.2463403288398008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}