{"id":"W1988960892","doi":"10.1099/mic.0.26411-0","title":"Foreign signal peptides can constitute a barrier to functional expression of periplasmic proteins in Haemophilus influenzae","year":2003,"lang":"en","type":"article","venue":"Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Periplasmic space; Neisseria gonorrhoeae; Haemophilus influenzae; Signal peptide; Transferrin; Microbiology; Biology; Biochemistry; Gene; Peptide sequence; Chemistry; Escherichia coli; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000258144,0.0002432969,0.0002614365,0.00009859813,0.0001126973,0.0003675825,0.0002009124,0.0003086799,0.0003463338],"category_scores_gemma":[0.0003758651,0.0001868948,0.0001847525,0.00009866209,0.0002796972,0.0002331699,0.0002507444,0.0004411796,0.0001844798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551511,"about_ca_system_score_gemma":0.0001078581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002825088,"about_ca_topic_score_gemma":0.0004960187,"domain_scores_codex":[0.9998347,0.00005554217,0.00001654281,0.00001609202,0.00005426387,0.00002287766],"domain_scores_gemma":[0.999731,0.0001171521,0.00006609481,0.00003077043,0.00002220284,0.00003275461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003320697,0.000005834954,0.00005763651,0.00001600774,0.000002036002,0.00002480493,0.000009582397,0.00004039437,0.9995359,0.00004469117,0.000003840985,0.0002261242],"study_design_scores_gemma":[0.00000653099,0.0002040224,0.001063264,0.000005478935,0.00001050144,0.0002239733,0.00002578265,0.0004720359,0.9969723,0.00003911548,0.0009734966,0.000003597137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966124,0.000595598,0.002430011,0.00003709818,0.000007234611,0.00001245674,0.00004014874,0.00001860476,0.0002464607],"genre_scores_gemma":[0.9947307,0.0003859616,0.004063795,0.00003659461,0.000005278277,0.00001954057,0.0001858784,0.00001786415,0.0005542273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003675825,"threshold_uncertainty_score":0.001851261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101291435036838,"score_gpt":0.2236100365187201,"score_spread":0.2134808930150363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}