{"id":"W1988967544","doi":"10.1038/mt.2014.243","title":"Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"Oncolytic virus; Medicine; Vaccinia; Pediatric cancer; Cancer; Virus; Immunology; Internal medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007746964,0.0009720484,0.001321084,0.0002347747,0.0003046601,0.0005149674,0.00044055,0.0007142934,0.001034077],"category_scores_gemma":[0.0005282689,0.0003876503,0.0005819052,0.0002741861,0.0004536739,0.000486837,0.0002506043,0.002051424,0.0002459449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007199912,"about_ca_system_score_gemma":0.001210079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000958306,"about_ca_topic_score_gemma":0.001385057,"domain_scores_codex":[0.9996699,0.0001494906,0.00001632405,0.00006210963,0.00003764102,0.00006454113],"domain_scores_gemma":[0.9996477,0.00006924026,0.00007548269,0.00003745041,0.00004317427,0.0001270437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1762172,0.1196346,0.02836788,0.0009723396,0.001050618,0.001885867,0.001644974,0.01116857,0.449516,0.001191501,0.006269426,0.202081],"study_design_scores_gemma":[0.05188312,0.8393048,0.03018099,0.00004631355,0.0004878398,0.002031588,0.0002021765,0.003581967,0.06315448,0.0002332487,0.00885616,0.00003737396],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953849,0.001012521,0.001164217,0.0001163132,0.00003476625,0.001137947,0.000470835,0.00005180191,0.0006267189],"genre_scores_gemma":[0.9913476,0.001478373,0.002844552,0.0002834379,0.00005895369,0.001706319,0.001331173,0.00003058547,0.0009189834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321084,"threshold_uncertainty_score":0.00522393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543497354646158,"score_gpt":0.3305967925986338,"score_spread":0.3151618190521723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}