{"id":"W1988967544","doi":"10.1038/mt.2014.243","title":"Phase 1 Study of Intratumoral Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus, in Pediatric Cancer Patients","year":2014,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"Oncolytic virus; Medicine; Vaccinia; Pediatric cancer; Cancer; Virus; Immunology; Internal medicine; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004460138,0.000288674,0.0003329028,0.0001909827,0.00006411672,0.00003651267,0.0003773143,0.000140306,0.00003990873],"category_scores_gemma":[0.00002002416,0.0002754319,0.00006727103,0.0003055412,0.00005794614,0.00001151283,0.00007162654,0.0001903862,0.000003028185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003263206,"about_ca_system_score_gemma":0.0001158926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002469156,"about_ca_topic_score_gemma":0.0006402637,"domain_scores_codex":[0.9977663,0.000546222,0.0003997091,0.0005615272,0.0003272425,0.0003990316],"domain_scores_gemma":[0.9989613,0.0000163411,0.0001428958,0.0006264854,0.0001290418,0.0001239877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005609088,0.004939811,0.03713812,0.00001818676,0.0001111206,0.000006390258,0.0005541196,0.0000673176,0.9095893,0.000004096136,0.00001412696,0.04194835],"study_design_scores_gemma":[0.03424226,0.08240093,0.06502092,0.00001633487,0.00005453904,0.000002601813,0.0001409192,0.0004572739,0.8161637,0.00009210873,0.0007032792,0.0007051529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957182,0.003229412,0.00003868472,0.00003562326,0.0000708579,0.00084938,0.00001418741,0.00001239267,0.00003122452],"genre_scores_gemma":[0.9975302,0.001699349,0.00002853962,0.0003644433,0.0001033312,0.000130977,0.00004634034,0.00007285393,0.0000240149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09342559,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543497354646158,"score_gpt":0.3305967925986338,"score_spread":0.3151618190521723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}