{"id":"W1988994846","doi":"10.1002/iub.1007","title":"Gene expression‐targeted isoflavone therapy","year":2012,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Genistein; Isoflavones; Substrate reduction therapy; Genetic enhancement; Gene; Bioinformatics; Signal transduction; Gene expression; Biology; Clinical trial; Pharmacology; Medicine; Computational biology; Cancer research; Enzyme replacement therapy; Cell biology; Biochemistry; Genetics; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000115468,0.0003658904,0.0006186462,0.00004273206,0.00009776961,0.00002644514,0.0002602132,0.0006732648,0.00009204045],"category_scores_gemma":[0.00003085934,0.0002453414,0.0003003576,0.00007938204,0.00003513481,0.000003628438,0.00007385528,0.0001640605,0.0001757509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001397208,"about_ca_system_score_gemma":0.0002769259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001150866,"about_ca_topic_score_gemma":0.00001056426,"domain_scores_codex":[0.9987205,0.0001366964,0.0003319075,0.0003858552,0.0001350021,0.0002900436],"domain_scores_gemma":[0.9991055,0.000009423172,0.0002071199,0.000444246,0.00004829781,0.0001854791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002168281,0.0001351667,0.000005642362,0.001033652,0.0003821732,0.000006909475,0.00003997705,0.000001140621,0.1477611,0.00001119633,0.09561127,0.7549901],"study_design_scores_gemma":[0.0001404021,0.00004166687,0.00000127467,0.0002758409,0.0001203394,0.00003707874,0.000001918291,1.186141e-7,0.03732719,8.551931e-7,0.9617235,0.0003297837],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008287699,0.9983212,0.0001118803,0.00002330576,0.0005682127,0.0003786917,0.0001072243,0.0000251092,0.0003815344],"genre_scores_gemma":[0.0000820174,0.987089,0.0003497986,0.0001852973,0.00358511,0.0001059309,0.004253971,0.00005827786,0.004290559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8661122,"threshold_uncertainty_score":0.9999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05472886325500033,"score_gpt":0.3077228557174845,"score_spread":0.2529939924624842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}