{"id":"W1989008863","doi":"10.1021/bi0120502","title":"Polar Residues in Membrane Domains of Proteins:  Molecular Basis for Helix−Helix Association in a Mutant CFTR Transmembrane Segment","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Transmembrane protein; Transmembrane domain; Hydrogen bond; Chemistry; Helix (gastropod); Side chain; Dimer; Mutant; Mutagenesis; Protein structure; Membrane protein; Cystic fibrosis transmembrane conductance regulator; Crystallography; Biophysics; Stereochemistry; Membrane; Biochemistry; Biology; Gene; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900763,0.0001805177,0.0004405812,0.000146563,0.00002344182,0.00001143951,0.0001331684,0.0001905048,0.000146568],"category_scores_gemma":[0.001562068,0.0001776137,0.0001306463,0.0003992121,0.00005627703,0.00005542881,0.00002354439,0.0002075683,0.00000430594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005841759,"about_ca_system_score_gemma":0.0001064645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001440546,"about_ca_topic_score_gemma":0.00006696249,"domain_scores_codex":[0.9980255,0.00005079804,0.0005054213,0.0003651972,0.0006175219,0.0004355675],"domain_scores_gemma":[0.9991162,0.0001896144,0.0001354915,0.0003156944,0.00012217,0.0001208038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004106558,0.0004685931,0.002351176,0.001803106,0.00005005254,0.00005866349,0.0002242165,0.0000176977,0.9937137,0.00000723726,0.0000786605,0.000816285],"study_design_scores_gemma":[0.00332607,0.0002343986,0.001888484,0.000902504,0.00003197399,0.000009866483,0.0001882053,0.0003807587,0.9924356,0.00003878683,0.0004085013,0.0001548019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929503,0.003014202,0.0002224975,0.001847189,0.00002049147,0.001241963,0.0001743223,0.00002707266,0.0005020159],"genre_scores_gemma":[0.9920374,0.0003087444,0.006634624,0.00006875471,0.0000552276,0.0002800334,0.00005704084,0.00002853703,0.0005296794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006412126,"threshold_uncertainty_score":0.7242877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081174125476843,"score_gpt":0.2691382618811634,"score_spread":0.2583265206263949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}