{"id":"W1989009222","doi":"10.1097/01.tp.0000440951.29757.bd","title":"Pharmacokinetics and Pharmacodynamics of ASKP1240, a Fully Human Anti-CD40 Antibody, in Normal and Renal Transplanted Cynomolgus Monkeys","year":2014,"lang":"en","type":"article","venue":"Transplantation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"Kyowa Hakko Kirin","keywords":"Pharmacokinetics; Pharmacodynamics; Medicine; Pharmacology; Receptor; Antibody; Kidney; Internal medicine; Urology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002132636,0.0002034541,0.0003165872,0.0002201116,0.0001297619,0.0002596876,0.0001024147,0.0002115156,0.0004143381],"category_scores_gemma":[0.0002738352,0.0001051803,0.0001712973,0.0001387336,0.0002776646,0.000251583,0.00007673648,0.0004564247,0.0001673868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083869,"about_ca_system_score_gemma":0.0002755372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007813203,"about_ca_topic_score_gemma":0.0007992043,"domain_scores_codex":[0.9998875,0.00002305775,0.000007813803,0.00002393791,0.00003532049,0.00002240927],"domain_scores_gemma":[0.9998564,0.00002268059,0.00004864107,0.00001761421,0.00001691162,0.00003782914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004055365,0.0004771347,0.007890813,0.00007603682,0.00004154428,0.0001540563,0.0001048097,0.0006708275,0.9716916,0.00007520724,0.0001755828,0.01458699],"study_design_scores_gemma":[0.0005225329,0.06054239,0.2001172,0.00002211486,0.0003922397,0.003704105,0.0002420342,0.01165586,0.7161119,0.0002982313,0.006340077,0.00005122341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987348,0.0005114989,0.0003990942,0.00001906264,0.000004433978,0.00001147094,0.00007054498,0.00002367693,0.0002253426],"genre_scores_gemma":[0.9986479,0.0002995484,0.0004502629,0.00003245537,0.000009178839,0.00002654529,0.0001709271,0.000008282968,0.0003549962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007813203,"threshold_uncertainty_score":0.002963006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007849762801684371,"score_gpt":0.2515968244052631,"score_spread":0.2437470616035787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}