{"id":"W1989009222","doi":"10.1097/01.tp.0000440951.29757.bd","title":"Pharmacokinetics and Pharmacodynamics of ASKP1240, a Fully Human Anti-CD40 Antibody, in Normal and Renal Transplanted Cynomolgus Monkeys","year":2014,"lang":"en","type":"article","venue":"Transplantation","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal","funders":"Kyowa Hakko Kirin","keywords":"Pharmacokinetics; Pharmacodynamics; Medicine; Pharmacology; Receptor; Antibody; Kidney; Internal medicine; Urology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193817,0.000218105,0.0003543828,0.000223337,0.0001091057,0.000009167622,0.0001209128,0.0002209888,0.00008653375],"category_scores_gemma":[0.000002949548,0.0002140898,0.00004222847,0.0001257184,0.0003092341,0.0001180213,0.00001340545,0.0003044058,0.000009646275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008559253,"about_ca_system_score_gemma":0.00001557557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002935515,"about_ca_topic_score_gemma":0.0001468472,"domain_scores_codex":[0.9986871,0.0002171456,0.0004407079,0.0002989016,0.00004209224,0.0003140856],"domain_scores_gemma":[0.9995949,0.0001081519,0.0001253776,0.0001082726,0.00003688649,0.00002643153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005006436,0.000141817,0.01430547,0.0002811084,0.00008619548,0.000022053,0.001412616,0.00005242277,0.980507,0.0003886201,0.000007500581,0.002294566],"study_design_scores_gemma":[0.00985536,0.0004221906,0.06039177,0.0001565933,0.0002902698,0.0004077156,0.00005999163,0.0006739581,0.9269046,0.0001037458,0.0004070566,0.0003268179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959102,0.000613386,0.002232593,0.00006160425,0.0001802884,0.0002167549,0.0001155418,0.00004288188,0.0006267112],"genre_scores_gemma":[0.9959356,0.003071109,0.0001023688,0.00004924491,0.00001763707,0.000007136036,0.0006887401,0.00001773851,0.0001104052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05360246,"threshold_uncertainty_score":0.8730329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007849762801684371,"score_gpt":0.2515968244052631,"score_spread":0.2437470616035787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}