{"id":"W1989014719","doi":"10.1016/j.febslet.2012.07.058","title":"Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center","year":2012,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Bimetal; Phosphodiesterase; In vitro; Enzyme; Boron; Catechol; Biochemistry; Stereochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659619,0.0001954341,0.0001648281,0.00009751282,0.00007175667,0.00001996984,0.0001103754,0.0001055797,0.00004999289],"category_scores_gemma":[0.00003499885,0.0001807877,0.0001352841,0.0001246133,0.00006082435,0.00001771983,0.00007518277,0.00007050147,0.00002941538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004005053,"about_ca_system_score_gemma":0.0000216891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002517813,"about_ca_topic_score_gemma":0.00001253184,"domain_scores_codex":[0.9989102,0.00003451401,0.0002554911,0.0002607454,0.0001822307,0.0003568023],"domain_scores_gemma":[0.9993753,0.00001178379,0.0001108839,0.0002949666,0.00004211987,0.0001649567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000148747,0.0001431009,0.02857503,0.0000208107,0.00004047407,6.834009e-7,0.0001143702,0.0001758615,0.956354,0.000007650124,0.01380739,0.0006119267],"study_design_scores_gemma":[0.0009290052,0.0001171611,0.01510488,0.00003710128,0.00002253917,0.000005967875,0.00004812252,0.00003490553,0.9053469,2.326095e-7,0.07810798,0.0002451997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906943,0.0001320806,0.006256422,0.001265211,0.001178712,0.0002094033,0.0000627906,0.00002005548,0.0001810682],"genre_scores_gemma":[0.9929186,0.000004238878,0.001789915,0.004295186,0.0004197917,0.00001946518,0.0002818869,0.00003003065,0.000240875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0643006,"threshold_uncertainty_score":0.7372308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248766838825154,"score_gpt":0.2375271607134349,"score_spread":0.2250394923251834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}