{"id":"W1989046662","doi":"10.1021/bi035224j","title":"Steady-State Kinetics and Molecular Evolution of <i>Escherichia coli</i> MenD [(1<i>R</i>,6<i>R</i>)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate Synthase], an Anomalous Thiamin Diphosphate-Dependent Decarboxylase−Carboligase","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Carboxylate; Kinetics; ATP synthase; Escherichia coli; Chemistry; Enzyme kinetics; Biochemistry; Enzyme; Physics; Active site; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000248752,0.000284195,0.0002524299,0.0002254432,0.0001440721,0.0006214665,0.0004089588,0.0003352248,0.0004583074],"category_scores_gemma":[0.0006021722,0.0002052077,0.0002101735,0.0002362405,0.0002208684,0.000350831,0.0001695792,0.0005101201,0.0002856108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009779712,"about_ca_system_score_gemma":0.0002113994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002137238,"about_ca_topic_score_gemma":0.001185262,"domain_scores_codex":[0.999856,0.00001775022,0.000007819521,0.00005087005,0.00003392475,0.00003347686],"domain_scores_gemma":[0.9995723,0.0001436186,0.00008961491,0.00004349218,0.00009279775,0.00005809999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003042386,0.0001735299,0.004986824,0.0000672721,0.00002663533,0.0000506606,0.00009364037,0.003999081,0.982819,0.001215038,0.0002916167,0.005972501],"study_design_scores_gemma":[0.0000332114,0.0003971116,0.02429027,0.00001474228,0.00004504052,0.00009497859,0.00009866693,0.07477237,0.8962224,0.000556834,0.003408874,0.00006541194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951208,0.0003467907,0.002973535,0.00008124099,0.00001821321,0.00001873846,0.0004637237,0.0001073419,0.0008695931],"genre_scores_gemma":[0.9947824,0.0003381123,0.002663838,0.00002817077,0.000006561374,0.00002972318,0.0009166304,0.00004559534,0.001188964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002137238,"threshold_uncertainty_score":0.007095754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005530617984649116,"score_gpt":0.227842943122002,"score_spread":0.2223123251373529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}