{"id":"W1989047374","doi":"10.1111/nmo.12390","title":"Activation of the endogenous nociceptin system by selective nociceptin receptor agonist <scp>SCH</scp> 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea‐predominant <scp>IBS</scp>","year":2014,"lang":"en","type":"article","venue":"Neurogastroenterology & Motility","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Uniwersytet Łódzki; Deutsche Forschungsgemeinschaft","keywords":"NOP; Nociceptin receptor; Agonist; In vivo; Irritable bowel syndrome; Pharmacology; Endogeny; Endogenous agonist; Receptor; Nociception; Partial agonist; Medicine; Diarrhea; Chemistry; Opioid; Opioid peptide; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000919354,0.0003229503,0.000230251,0.0001452826,0.0001117155,0.0001148481,0.0001747765,0.0002070402,0.001553159],"category_scores_gemma":[0.00005508071,0.000085732,0.0002057442,0.00009996806,0.0001376901,0.0001096294,0.0001460967,0.0005036562,0.0003448244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679982,"about_ca_system_score_gemma":0.0001781347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002721671,"about_ca_topic_score_gemma":0.0005792202,"domain_scores_codex":[0.9999412,0.000009753825,0.000006218965,0.000008761694,0.00001400792,0.00001998021],"domain_scores_gemma":[0.9999685,0.000003657198,0.00001173762,0.000002477262,0.000004370303,0.000009285237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002917412,0.0000547362,0.0001621547,0.00009358033,0.000005347806,0.00007430193,0.000004126639,0.00004601771,0.9967393,0.00003237685,0.00006004646,0.002436254],"study_design_scores_gemma":[0.0001734713,0.005343735,0.009901253,0.00002544659,0.00005264084,0.001163722,0.0000284569,0.0006576866,0.9799526,0.00003547204,0.00265623,0.000009213411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993257,0.003360045,0.001185078,0.0001355518,0.00003047145,0.00006190773,0.0003007634,0.00003601272,0.001633172],"genre_scores_gemma":[0.9934672,0.003140968,0.00159918,0.0001200909,0.00002793434,0.00006031747,0.0005130074,0.00000599027,0.001065326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553159,"threshold_uncertainty_score":0.005195796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705475830668111,"score_gpt":0.2379793230146294,"score_spread":0.2209245647079482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}