{"id":"W1989047374","doi":"10.1111/nmo.12390","title":"Activation of the endogenous nociceptin system by selective nociceptin receptor agonist <scp>SCH</scp> 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea‐predominant <scp>IBS</scp>","year":2014,"lang":"en","type":"article","venue":"Neurogastroenterology & Motility","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Uniwersytet Łódzki; Deutsche Forschungsgemeinschaft","keywords":"NOP; Nociceptin receptor; Agonist; In vivo; Irritable bowel syndrome; Pharmacology; Endogeny; Endogenous agonist; Receptor; Nociception; Partial agonist; Medicine; Diarrhea; Chemistry; Opioid; Opioid peptide; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007313846,0.0006217863,0.001394776,0.000132716,0.0002803606,0.00002664703,0.0002710601,0.0002417042,0.000003761004],"category_scores_gemma":[0.001724402,0.0004763649,0.0004508413,0.0002781241,0.0008929236,0.0001477892,0.00007728476,0.0003344745,0.000002868169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001565642,"about_ca_system_score_gemma":0.0001183678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004209997,"about_ca_topic_score_gemma":0.0001112717,"domain_scores_codex":[0.9959355,0.0008062004,0.0009077396,0.00111984,0.0003855166,0.0008452311],"domain_scores_gemma":[0.9961348,0.001576778,0.0008422406,0.0006893732,0.0005233892,0.0002334403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004108828,0.001972554,0.5120459,0.001112035,0.0002655987,0.000001959153,0.001658186,0.0000521331,0.4811169,0.00001830153,0.0001944023,0.001151214],"study_design_scores_gemma":[0.008306783,0.01793711,0.6563299,0.0002289071,0.0006611442,0.0002027267,0.001423105,0.0009084777,0.3137417,0.00001133672,0.0002183867,0.00003038853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917008,0.00007931789,0.003408435,0.0002744386,0.0002028317,0.003528282,0.0005287688,0.00007972471,0.0001974399],"genre_scores_gemma":[0.9985312,0.0000194504,0.0007980136,0.0001021142,0.00009391362,0.0002120569,0.0001183701,0.00005536051,0.00006958195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1673752,"threshold_uncertainty_score":0.9997688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705475830668111,"score_gpt":0.2379793230146294,"score_spread":0.2209245647079482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}