{"id":"W1989069545","doi":"10.1074/jbc.m113.512046","title":"A Novel Glucagon-like Peptide-1 (GLP-1)/Glucagon Hybrid Peptide with Triple-acting Agonist Activity at Glucose-dependent Insulinotropic Polypeptide, GLP-1, and Glucagon Receptors and Therapeutic Potential in High Fat-fed Mice","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Lausanne; University of Toronto; Ulster University; Diabetes Research and Wellness Foundation","keywords":"Glucagon-like peptide-1; Glucagon-like peptide 1 receptor; Glucagon; Endocrinology; Internal medicine; Receptor; Agonist; Peptide; Chemistry; Medicine; Insulin; Diabetes mellitus; Type 2 diabetes; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001240821,0.0004622838,0.0002945019,0.0002041726,0.0001008349,0.000282754,0.0002103136,0.0003241051,0.0004127924],"category_scores_gemma":[0.00006097477,0.0001450771,0.0001981286,0.0001296136,0.0001650579,0.0002557239,0.0001907582,0.0005080969,0.000113173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490149,"about_ca_system_score_gemma":0.0001037034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001183556,"about_ca_topic_score_gemma":0.0002069913,"domain_scores_codex":[0.9999324,0.00001419514,0.000005756726,0.00001523934,0.00001772637,0.00001470013],"domain_scores_gemma":[0.9999382,0.000004933027,0.00001797046,0.000003518865,0.000005515327,0.00002978917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003309971,0.00004149843,0.0001342325,0.00004515657,0.0000128238,0.0001248707,0.000007014804,0.0001124961,0.9973812,0.00007243655,0.00003845312,0.001698875],"study_design_scores_gemma":[0.000426978,0.005941396,0.004569483,0.00001136954,0.0001328923,0.002032285,0.0000386749,0.001852117,0.97808,0.00008862055,0.006789935,0.00003616246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994197,0.001735027,0.003019368,0.00007373743,0.00004057804,0.00004126677,0.0002162876,0.00006296819,0.0006137916],"genre_scores_gemma":[0.990031,0.001192229,0.006744277,0.0001441253,0.000034563,0.0000793642,0.0006174812,0.00001766594,0.001139226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004622838,"threshold_uncertainty_score":0.00138092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587934386549928,"score_gpt":0.2313202070687385,"score_spread":0.2154408632032392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}