{"id":"W1989069545","doi":"10.1074/jbc.m113.512046","title":"A Novel Glucagon-like Peptide-1 (GLP-1)/Glucagon Hybrid Peptide with Triple-acting Agonist Activity at Glucose-dependent Insulinotropic Polypeptide, GLP-1, and Glucagon Receptors and Therapeutic Potential in High Fat-fed Mice","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Lausanne; University of Toronto; Ulster University; Diabetes Research and Wellness Foundation","keywords":"Glucagon-like peptide-1; Glucagon-like peptide 1 receptor; Glucagon; Endocrinology; Internal medicine; Receptor; Agonist; Peptide; Chemistry; Medicine; Insulin; Diabetes mellitus; Type 2 diabetes; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003093947,0.0005240079,0.0009466603,0.0001166828,0.000167221,0.0001257066,0.0002052912,0.0002516887,0.0002536997],"category_scores_gemma":[0.0001080354,0.0003480034,0.000184356,0.000186171,0.0002914596,0.0002211699,0.0002406324,0.0006728867,0.0000118273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004316571,"about_ca_system_score_gemma":0.00008088781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002682706,"about_ca_topic_score_gemma":0.00002104647,"domain_scores_codex":[0.9975224,0.00007963816,0.0007277639,0.0005928584,0.0004488196,0.0006285231],"domain_scores_gemma":[0.998274,0.0001567288,0.0007091074,0.0002760072,0.0001575707,0.0004266186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002663091,0.0009946146,0.03625853,0.0002162542,0.0005255441,0.0002428458,0.00008996954,0.000008230611,0.9349995,0.000004090503,0.0001944208,0.02380293],"study_design_scores_gemma":[0.01820032,0.004025117,0.252626,0.0006562614,0.0007505642,0.001188092,0.001010232,0.0002646731,0.7174671,0.0001258039,0.002756292,0.0009295447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962344,0.001420987,0.0001315845,0.0008657447,0.000203204,0.0005593262,0.00001175975,0.0000461388,0.0005268267],"genre_scores_gemma":[0.9953716,0.0009470226,0.001487347,0.0003164522,0.0003192498,0.0000330102,0.00002896172,0.00004026982,0.001456128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2175324,"threshold_uncertainty_score":0.9998972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587934386549928,"score_gpt":0.2313202070687385,"score_spread":0.2154408632032392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}