{"id":"W1989090824","doi":"10.1196/annals.1359.001","title":"Knock‐down of the Cytoprotective Gene, Clusterin, to Enhance Hormone and Chemosensitivity in Prostate and Other Cancers","year":2005,"lang":"en","type":"review","venue":"Annals of the New York Academy of Sciences","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Clusterin; Cancer research; Apoptosis; Downregulation and upregulation; Prostate; Prostate cancer; Medicine; Biology; Gene; Oncology; Internal medicine; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001058178,0.0002566163,0.001178484,0.0001587065,0.00007072643,0.000007415987,0.0004847019,0.0001832203,0.00000499692],"category_scores_gemma":[0.0002956525,0.0001420402,0.0001780602,0.0008287857,0.001638648,0.000055195,0.0005592364,0.0003616244,6.923752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003970883,"about_ca_system_score_gemma":0.0003779602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004044371,"about_ca_topic_score_gemma":0.00005850585,"domain_scores_codex":[0.9980282,0.0002119207,0.0005940632,0.0004745147,0.000400844,0.0002905268],"domain_scores_gemma":[0.9987339,0.0001724112,0.0007187225,0.00021771,0.00004076857,0.0001164406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000256739,0.00006462968,0.0003743485,0.004248736,0.0001051837,0.000001358767,0.001578748,0.00004909504,0.004157372,0.00003284765,0.001550558,0.9875804],"study_design_scores_gemma":[0.001689499,0.001613207,0.06437332,0.06814795,0.001193744,0.0006414257,0.0006076912,0.0001138269,0.1044334,0.001914019,0.7539198,0.00135209],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.123503,0.8695249,0.000002073272,0.004845269,0.00004545666,0.001759138,0.00008568008,0.000005075551,0.0002294344],"genre_scores_gemma":[0.05782713,0.9396368,0.000434908,0.001531328,0.0001108986,0.00004524229,2.3036e-7,0.00002013892,0.0003933668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9862283,"threshold_uncertainty_score":0.6037665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1020476325467039,"score_gpt":0.4118873204027241,"score_spread":0.3098396878560202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}