{"id":"W1989111033","doi":"10.1038/ng.2939","title":"Low copy number of the salivary amylase gene predisposes to obesity","year":2014,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University; Ottawa Hospital; McGill Genome Centre; University of Ottawa","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Hospital for Sick Children; Ontario Ministry of Research and Innovation; Centre National de la Recherche Scientifique; Stiftelsen för Strategisk Forskning; Institut National de la Santé et de la Recherche Médicale; King's College London; Association Diabète Risque Vasculaire; Fédération Française de Cardiologie; British Skin Foundation; Fondation de France; Novo Nordisk; National Institute for Health and Care Research; Australian Government; Agence Nationale de la Recherche; Biotechnology and Biological Sciences Research Council; Imperial College Healthcare NHS Trust; Wellcome Trust; Ontario Genomics; Centre Hospitalier Universitaire de Rennes; Eli Lilly and Company; Genome Canada; Ontario Innovation Trust; Vetenskapsrådet; Brigham and Women's Hospital; Directorate for Biological Sciences; Imperial College London; Medical Research Council; Les Laboratories Pierre Fabre; Qatar Foundation; National Institute of General Medical Sciences; European Renal Association-European Dialysis and Transplant Association; Centre hospitalier régional universitaire de Lille; Ontario Genomics Institute; Sanofi","keywords":"Copy-number variation; Biology; Odds ratio; Obesity; Genetics; Allele; Body mass index; Gene dosage; Genome-wide association study; Gene; Internal medicine; Gene expression; Endocrinology; Single-nucleotide polymorphism; Genotype; Genome; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001118325,0.0001058543,0.0002001801,0.00002573584,0.00004008551,0.000005756016,0.0001151329,0.0002009169,0.0001849625],"category_scores_gemma":[0.0003905706,0.00006918541,0.00008084483,0.000187946,0.00005037562,0.000009530403,0.0000597753,0.0002324011,0.00006801874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002012734,"about_ca_system_score_gemma":0.00005867015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003805256,"about_ca_topic_score_gemma":0.000001980721,"domain_scores_codex":[0.9992139,0.00004202412,0.0001545004,0.000159862,0.0002803285,0.0001493276],"domain_scores_gemma":[0.9991454,0.0000791007,0.00005140469,0.0004564921,0.0001374594,0.0001300904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001288792,0.0002586058,0.9091138,0.0001433409,0.0000644938,0.000001924636,0.0001389244,0.00005300044,0.05008346,0.0002019948,0.03763635,0.002175215],"study_design_scores_gemma":[0.0006059925,0.0001162671,0.4533799,0.00006910614,0.00009995729,0.00001189254,0.00001160658,0.0001490259,0.5275766,0.0001788998,0.01772075,0.00008001464],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907179,0.0003542616,0.0001729268,0.0004821979,0.0006019057,0.0002330008,0.00002117842,0.00002844864,0.007388216],"genre_scores_gemma":[0.9896316,0.00003006316,0.004457532,0.004104939,0.000354898,0.000004810287,0.00001088687,0.00001451046,0.001390791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4774931,"threshold_uncertainty_score":0.2821299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005696118346484886,"score_gpt":0.2560734842389138,"score_spread":0.2503773658924289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}