{"id":"W1989111033","doi":"10.1038/ng.2939","title":"Low copy number of the salivary amylase gene predisposes to obesity","year":2014,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University; Ottawa Hospital; McGill Genome Centre; University of Ottawa","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; Novartis Pharma; National Institutes of Health; Hospital for Sick Children; Ontario Ministry of Research and Innovation; Centre National de la Recherche Scientifique; Stiftelsen för Strategisk Forskning; Institut National de la Santé et de la Recherche Médicale; King's College London; Association Diabète Risque Vasculaire; Fédération Française de Cardiologie; British Skin Foundation; Fondation de France; Novo Nordisk; National Institute for Health and Care Research; Australian Government; Agence Nationale de la Recherche; Biotechnology and Biological Sciences Research Council; Imperial College Healthcare NHS Trust; Wellcome Trust; Ontario Genomics; Centre Hospitalier Universitaire de Rennes; Eli Lilly and Company; Genome Canada; Ontario Innovation Trust; Vetenskapsrådet; Brigham and Women's Hospital; Directorate for Biological Sciences; Imperial College London; Medical Research Council; Les Laboratories Pierre Fabre; Qatar Foundation; National Institute of General Medical Sciences; European Renal Association-European Dialysis and Transplant Association; Centre hospitalier régional universitaire de Lille; Ontario Genomics Institute; Sanofi","keywords":"Copy-number variation; Biology; Odds ratio; Obesity; Genetics; Allele; Body mass index; Gene dosage; Genome-wide association study; Gene; Internal medicine; Gene expression; Endocrinology; Single-nucleotide polymorphism; Genotype; Genome; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003393605,0.001364453,0.0004885554,0.002733619,0.0005956499,0.0006804049,0.0006813165,0.001658341,0.006786161],"category_scores_gemma":[0.002249038,0.0006643805,0.000694643,0.001057327,0.0006623195,0.0003187727,0.0006116133,0.001127247,0.000486407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166035,"about_ca_system_score_gemma":0.0001925829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008106824,"about_ca_topic_score_gemma":0.0004473381,"domain_scores_codex":[0.9994423,0.0001864422,0.00006423044,0.0001249857,0.0001254452,0.0000565621],"domain_scores_gemma":[0.9985252,0.000652589,0.0004062854,0.0001224894,0.0000613192,0.0002321543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006359888,0.0007799937,0.3266598,0.0001994255,0.0008605884,0.06302793,0.001217661,0.00111527,0.580851,0.002947916,0.001391756,0.01458873],"study_design_scores_gemma":[0.0002954909,0.001200984,0.8235784,0.0001365957,0.001127616,0.1218134,0.001110616,0.004862797,0.03838107,0.004462969,0.002865878,0.0001640983],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963049,0.0003125496,0.001498632,0.0004243973,0.00007673031,0.00001210348,0.0001993325,0.00008083377,0.001090612],"genre_scores_gemma":[0.9984404,0.0001768091,0.0006235745,0.00004645149,0.00007482837,0.000006634698,0.00007246157,0.00003159145,0.0005271707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006786161,"threshold_uncertainty_score":0.02270198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005696118346484886,"score_gpt":0.2560734842389138,"score_spread":0.2503773658924289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}