{"id":"W1989151603","doi":"10.1074/jbc.m709522200","title":"Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Matrix metalloproteinase; Encephalomyelitis; Immunology; Collagenase; Pathogenesis; Myelin; Autoimmune disease; Medicine; Central nervous system; Biology; Enzyme; Neuroscience; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003936882,0.001714994,0.0005912897,0.001193457,0.0002584161,0.0007002585,0.0006065042,0.0009818919,0.002573645],"category_scores_gemma":[0.0002787173,0.0005365709,0.0004377993,0.0003920079,0.0005898128,0.0004240556,0.0002951588,0.001551391,0.001273633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006528909,"about_ca_system_score_gemma":0.0004559837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001113359,"about_ca_topic_score_gemma":0.00172016,"domain_scores_codex":[0.9994997,0.00008537293,0.00005957439,0.0001397643,0.0001017602,0.000113823],"domain_scores_gemma":[0.9991473,0.0001218815,0.0003383925,0.00007397225,0.0000422653,0.0002761197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005221461,0.0002239882,0.0001833938,0.00005562755,0.00001930767,0.0001278894,0.00001988006,0.00009733283,0.9972165,0.0002774559,0.0001316023,0.001124979],"study_design_scores_gemma":[0.0004262141,0.002341519,0.008856778,0.00007579781,0.0001145809,0.001480279,0.00006808691,0.002321616,0.9781411,0.0003993638,0.005749969,0.00002478449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815288,0.003593741,0.004902371,0.000570951,0.0001735094,0.0001696004,0.003239736,0.001044986,0.004776308],"genre_scores_gemma":[0.9656596,0.004182328,0.009104344,0.0004192294,0.0001259409,0.0003379647,0.003663137,0.0003146979,0.01619274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002573645,"threshold_uncertainty_score":0.008609653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167564464671667,"score_gpt":0.2533302713730064,"score_spread":0.2316546267262897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}