{"id":"W1989169565","doi":"10.1371/journal.pone.0053155","title":"DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Institute of Nutrition, Metabolism and Diabetes; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Eye Institute; Canadian Institutes of Health Research; Deutsche Ophthalmologische Gesellschaft; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; National Institutes of Health; Charles H. Hood Foundation","keywords":"PPARGC1A; Biology; Peroxisome proliferator-activated receptor gamma; Coactivator; Peroxisome proliferator-activated receptor; Single-nucleotide polymorphism; Genetics; Factor H; Gene; Transcription factor; Cancer research; Complement system; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744287,0.000173906,0.0005607319,0.00008793414,0.00006498889,0.00001656986,0.00004680877,0.00006608204,0.00001982505],"category_scores_gemma":[0.00009736037,0.0001301031,0.00004059409,0.0002734351,0.000105863,0.00009122561,0.00002870156,0.0001163291,3.677642e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777525,"about_ca_system_score_gemma":0.00005869404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404947,"about_ca_topic_score_gemma":0.0003673912,"domain_scores_codex":[0.9985771,0.0001581017,0.0003960559,0.0002450345,0.000375994,0.0002476739],"domain_scores_gemma":[0.9991874,0.0001092494,0.0003247717,0.0001350371,0.0001561642,0.00008739008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001204774,0.0009633288,0.3832428,0.0001600465,0.0003071649,0.00002324221,0.0007081174,0.000009468993,0.614296,0.000006936774,0.000001276328,0.0001611327],"study_design_scores_gemma":[0.003674649,0.000315454,0.8981795,0.002832361,0.0003616933,0.000004318045,0.0007367035,0.006327764,0.08733692,0.000107266,1.487439e-7,0.0001232543],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984981,0.000265836,0.00001288827,0.000144446,0.000005894449,0.0009023705,0.0001290048,0.00001370618,0.00002772326],"genre_scores_gemma":[0.9991867,0.00009468737,0.0005410084,0.0000544674,0.000007822163,0.00001923503,0.00007102537,0.00001926769,0.000005795179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5269591,"threshold_uncertainty_score":0.5305449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09976990736970426,"score_gpt":0.247780056014601,"score_spread":0.1480101486448967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}