{"id":"W1989169565","doi":"10.1371/journal.pone.0053155","title":"DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Institute of Nutrition, Metabolism and Diabetes; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Eye Institute; Canadian Institutes of Health Research; Deutsche Ophthalmologische Gesellschaft; Deutsche Forschungsgemeinschaft; Research to Prevent Blindness; National Institutes of Health; Charles H. Hood Foundation","keywords":"PPARGC1A; Biology; Peroxisome proliferator-activated receptor gamma; Coactivator; Peroxisome proliferator-activated receptor; Single-nucleotide polymorphism; Genetics; Factor H; Gene; Transcription factor; Cancer research; Complement system; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000650257,0.000407823,0.0003591856,0.0009631829,0.000406163,0.000257231,0.0003661826,0.0005973792,0.00355412],"category_scores_gemma":[0.001646355,0.0001527455,0.0005857071,0.001123008,0.0005147232,0.0001353859,0.0002861324,0.0003160398,0.0002371518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050495,"about_ca_system_score_gemma":0.0002696359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004123283,"about_ca_topic_score_gemma":0.004050076,"domain_scores_codex":[0.9992275,0.0002190253,0.00007820693,0.0003189828,0.00009703555,0.0000591076],"domain_scores_gemma":[0.998975,0.0005044272,0.0003139063,0.00006840756,0.00004484181,0.00009328507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002144841,0.0001320191,0.9368952,0.0001016807,0.0006067129,0.00140496,0.0004567192,0.0007379426,0.0456525,0.0003809883,0.0003242469,0.01116229],"study_design_scores_gemma":[0.00007861391,0.000478526,0.9907063,0.00002082539,0.0002456126,0.002416781,0.0001938029,0.001637879,0.00305642,0.0004546144,0.0006972911,0.00001341161],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979412,0.0001749898,0.001008157,0.00003372816,0.000005541381,0.00001618258,0.0005885244,0.00001475388,0.0002167056],"genre_scores_gemma":[0.9981645,0.00004299487,0.001066059,0.0000283211,0.000006973877,0.00002601916,0.0004096921,0.000006860116,0.0002485394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004123283,"threshold_uncertainty_score":0.0118897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09976990736970426,"score_gpt":0.247780056014601,"score_spread":0.1480101486448967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}