{"id":"W1989175678","doi":"10.1021/bi0001067","title":"Conformational Changes in the PBX Homeodomain and C-Terminal Extension upon Binding DNA and HOX-Derived YPWM Peptides<sup>,</sup>","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Pacific Northwest National Laboratory; Biological and Environmental Research; Battelle; Medical Research Council; Medical Research Council Canada; U.S. Department of Energy","keywords":"Homeobox; Hox gene; DNA; Binding site; Amino acid; Peptide; Chemistry; Biology; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179707,0.0001322639,0.0001244811,0.00006245263,0.0001406469,0.0001662092,0.00017869,0.0001441328,0.001698451],"category_scores_gemma":[0.0002460808,0.0001139264,0.0001132699,0.00007828985,0.0002669399,0.0001740468,0.0001154599,0.0003253589,0.0002058768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203459,"about_ca_system_score_gemma":0.00008094626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006133015,"about_ca_topic_score_gemma":0.0007437082,"domain_scores_codex":[0.9999479,0.000008720463,0.000001739501,0.00001123891,0.00001259204,0.00001766715],"domain_scores_gemma":[0.9998717,0.000043903,0.00002686154,0.000006652438,0.00001219119,0.00003871183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006291459,0.00005040641,0.001105701,0.00004489742,0.00002416553,0.0002688612,0.0001294295,0.0003707533,0.9953895,0.0002376945,0.0001029265,0.001646613],"study_design_scores_gemma":[0.0000719466,0.0005908553,0.06052311,0.00001823284,0.0000378008,0.0008945215,0.0002142636,0.005008808,0.9302676,0.0002244341,0.002112529,0.00003584462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999263,0.0001273812,0.0002116359,0.00001693586,0.000003704693,0.000001559948,0.00002692508,0.000005004865,0.0003437596],"genre_scores_gemma":[0.9989979,0.00008941167,0.0001909243,0.00003122478,0.000002630405,0.000003829122,0.0001070458,0.000005160997,0.0005719488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698451,"threshold_uncertainty_score":0.005681932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006432223415429592,"score_gpt":0.2100969604984365,"score_spread":0.2036647370830069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}