{"id":"W1989175678","doi":"10.1021/bi0001067","title":"Conformational Changes in the PBX Homeodomain and C-Terminal Extension upon Binding DNA and HOX-Derived YPWM Peptides<sup>,</sup>","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Pacific Northwest National Laboratory; Biological and Environmental Research; Battelle; Medical Research Council; Medical Research Council Canada; U.S. Department of Energy","keywords":"Homeobox; Hox gene; DNA; Binding site; Amino acid; Peptide; Chemistry; Biology; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075912,0.0001681531,0.0001220727,0.00002526811,0.0001137584,0.00006301241,0.0001429727,0.0001678929,0.00003606185],"category_scores_gemma":[0.00002324096,0.0001422561,0.00003080319,0.00004922234,0.0001022922,0.000005016507,0.00007242202,0.00009673118,0.000003925064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001413125,"about_ca_system_score_gemma":0.00003409527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007045083,"about_ca_topic_score_gemma":0.000007667178,"domain_scores_codex":[0.9991961,0.00002737213,0.0001680242,0.0002813315,0.0001118969,0.0002153407],"domain_scores_gemma":[0.9996108,0.00001799384,0.00005704254,0.0002298663,0.00002295739,0.00006133617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004850725,0.00002870589,0.0005003242,0.00006688068,0.00001230823,0.000009660833,0.0002985085,0.00002067599,0.9949395,0.00001147297,0.0002958621,0.003767559],"study_design_scores_gemma":[0.002807202,0.0003628222,0.01965907,0.0001717397,0.00005556482,0.001353433,0.003774636,0.009879074,0.951061,0.0002211348,0.009661656,0.0009927137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983796,0.0004831932,0.000009385724,0.0003478035,0.00001467022,0.0001163046,0.00004529648,0.000006517848,0.0005972635],"genre_scores_gemma":[0.9980353,0.0006565202,0.0002970698,0.0002516495,0.0001380763,0.00001592901,0.0003002974,0.00001313662,0.0002919916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04387858,"threshold_uncertainty_score":0.5801037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006432223415429592,"score_gpt":0.2100969604984365,"score_spread":0.2036647370830069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}