{"id":"W1989191461","doi":"10.1046/j.1365-2141.2000.02126.x","title":"Porcine von Willebrand factor and thrombin induce the activation of c‐Jun amino‐terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal‐related kinase 2 (ERK2) in human platelets","year":2000,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; St. Michael's Hospital","funders":"Bayer Canada; Canadian Hemophilia Society","keywords":"Platelet activation; Kinase; Thrombin; MAPK/ERK pathway; Chemistry; Cell biology; Glycoprotein Ib; p38 mitogen-activated protein kinases; Platelet; Platelet membrane glycoprotein; Thrombin receptor; Mitogen-activated protein kinase; Molecular biology; Biochemistry; Biology; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002383648,0.0004460615,0.000217644,0.0002502765,0.0001445598,0.0002398215,0.0001123272,0.0003144044,0.001895122],"category_scores_gemma":[0.000208757,0.0001803175,0.0004566307,0.0002516749,0.000175388,0.0001869449,0.0001906979,0.0004762367,0.0004527748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001587841,"about_ca_system_score_gemma":0.000228511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003983173,"about_ca_topic_score_gemma":0.0005193952,"domain_scores_codex":[0.9997212,0.00004994824,0.00003084288,0.00004069296,0.00009158518,0.00006574921],"domain_scores_gemma":[0.9999294,0.00001507906,0.00001700185,0.000008795496,0.00000909222,0.00002053149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000388653,0.00007858861,0.000132529,0.00008464714,0.00001070434,0.0001148629,0.00002633921,0.00003049658,0.9975262,0.00007132329,0.0000607543,0.001474873],"study_design_scores_gemma":[0.0001121242,0.001892884,0.0194446,0.00001325583,0.0000439441,0.003253767,0.00005251842,0.000878582,0.9678742,0.0001737574,0.006249169,0.0000111604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846953,0.00753115,0.003807707,0.0001857231,0.0001092152,0.0001472576,0.0005110448,0.00004928786,0.002963552],"genre_scores_gemma":[0.9869441,0.002751801,0.00344328,0.0001190864,0.00004754636,0.0001805788,0.002143105,0.00001098252,0.004359512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001895122,"threshold_uncertainty_score":0.006339848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493880839794132,"score_gpt":0.2588660599708924,"score_spread":0.2439272515729511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}