{"id":"W1989194287","doi":"10.1016/j.chom.2014.01.012","title":"From Arrest to Escape: HIV-1 Vpr Cuts a Deal","year":2014,"lang":"en","type":"letter","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Endonuclease; Regulator; Cell biology; Innate immune system; Human immunodeficiency virus (HIV); Master regulator; Cell cycle checkpoint; Suppressor; Mechanism (biology); Cell; Cell cycle; Immune system; Virology; DNA; Genetics; Physics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0001400295,0.0007249895,0.0008550583,0.0002768721,0.0002625955,0.00008747606,0.0009461991,0.001708283,0.005268626],"category_scores_gemma":[0.00002669082,0.0006438161,0.0003325581,0.0001543809,0.0002369545,0.00004427502,0.0004016382,0.002387677,0.1841562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001984481,"about_ca_system_score_gemma":0.0002329147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151461,"about_ca_topic_score_gemma":0.0000664547,"domain_scores_codex":[0.9964164,0.0004359091,0.0004572996,0.001145689,0.00009856556,0.001446146],"domain_scores_gemma":[0.9981354,0.0003463186,0.0001682236,0.001120645,0.0001037845,0.0001256103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007786419,0.0001164494,0.0001519647,0.00005577782,0.0002967113,0.000515333,0.0002774684,2.718523e-7,0.2069486,0.000001170707,0.7908512,0.0007071795],"study_design_scores_gemma":[0.001556465,0.0002376083,0.0001916822,0.0001198211,0.0001348668,0.00004609721,0.00002537204,1.308712e-7,0.06300908,0.00001476992,0.9340863,0.000577785],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.06725036,0.02018405,0.0008675091,0.8445675,0.007039057,0.003778391,0.01515583,0.0006758363,0.04048146],"genre_scores_gemma":[0.01905718,0.0003336341,0.0009768307,0.6328225,0.005481442,0.0003745369,0.06003698,0.0003608119,0.2805561],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2400747,"threshold_uncertainty_score":0.9999139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122149844963977,"score_gpt":0.2381363298496653,"score_spread":0.2269148314000256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}