{"id":"W1989236715","doi":"10.1016/j.bmcl.2013.09.064","title":"Dual isotope labeling: Conjugation of 32P-oligonucleotides with 18F-aryltrifluoroborate via copper(I) catalyzed cycloaddition","year":2013,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; TRIUMF","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oligonucleotide; Bioconjugation; Cycloaddition; Conjugate; Conjugated system; Combinatorial chemistry; Azide; Oligonucleotide synthesis; Copper; Click chemistry; Polyacrylamide gel electrophoresis; Catalysis; Organic chemistry; Enzyme; Biochemistry; DNA; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005798902,0.0007272526,0.0005045877,0.0003888089,0.0003523874,0.0005206838,0.0007419452,0.0007598049,0.001536929],"category_scores_gemma":[0.0003795622,0.0005317189,0.0003071618,0.0002857124,0.0004211174,0.0004596944,0.000471131,0.000729276,0.0008402042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006833512,"about_ca_system_score_gemma":0.0003588028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007605351,"about_ca_topic_score_gemma":0.001271211,"domain_scores_codex":[0.999543,0.00007480577,0.00002766932,0.0001516619,0.00008182387,0.0001211191],"domain_scores_gemma":[0.9998412,0.00003403335,0.0000426095,0.00002615667,0.00002316424,0.00003293153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001070423,0.00001772431,0.00004724771,0.00004266297,0.000004213131,0.00009299399,0.00003044734,0.00007494008,0.9960667,0.0003418072,0.0001144283,0.003059848],"study_design_scores_gemma":[0.00001032886,0.0000851303,0.00009530513,0.000001546089,0.000005945856,0.0001235286,0.000003605491,0.0002720714,0.9976128,0.00002487084,0.001758976,0.000005839133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8691583,0.004119703,0.111592,0.0005438132,0.0002958042,0.0002910212,0.0006246043,0.001322744,0.01205186],"genre_scores_gemma":[0.9402337,0.001806564,0.04781049,0.0001078857,0.00006734236,0.000229302,0.0004355823,0.0001055418,0.009203575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536929,"threshold_uncertainty_score":0.005141556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007299551121879654,"score_gpt":0.199223521418544,"score_spread":0.1919239702966644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}