{"id":"W1989239876","doi":"10.1083/jcb.201408081","title":"Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis","year":2014,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Cytokinesis; Polo-like kinase; Cell biology; Biology; Aurora B kinase; Aurora inhibitor; PLK1; Allosteric regulation; Protein kinase domain; Midbody; Kinase; Cell division; Cell cycle; Biochemistry; Cell; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000700809,0.000219805,0.000140081,0.0001298798,0.0002240121,0.0002882932,0.0001551617,0.0001440007,0.001040415],"category_scores_gemma":[0.0001372422,0.0001605256,0.0001348191,0.00006036353,0.000211909,0.0001483011,0.0002896879,0.0002528987,0.0004500038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002503452,"about_ca_system_score_gemma":0.0001789609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002220257,"about_ca_topic_score_gemma":0.0005722555,"domain_scores_codex":[0.999899,0.00001402892,0.000009315057,0.00002308801,0.00002906308,0.00002544433],"domain_scores_gemma":[0.9998852,0.00001413008,0.00004040201,0.00001172429,0.000006797227,0.00004171183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001047445,0.00001543735,0.0005434011,0.00001464519,0.000002170715,0.00008999932,0.00000610694,0.00006342929,0.9982038,0.0001637624,0.00002527681,0.0007674081],"study_design_scores_gemma":[0.00002370478,0.00009658126,0.01835373,0.00000509035,0.000009718,0.0006344261,0.0000435037,0.002698769,0.976064,0.00018895,0.001874394,0.000007108945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973606,0.0003866248,0.0009162673,0.00004723326,0.00001404675,0.000005150161,0.00003893982,0.00005055534,0.001180499],"genre_scores_gemma":[0.9991893,0.0000849683,0.0002600127,0.00001050529,0.000003342477,0.00000431845,0.00004121357,0.000006414279,0.0003999016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040415,"threshold_uncertainty_score":0.003480554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005919586087390812,"score_gpt":0.2278757315700862,"score_spread":0.2219561454826954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}