{"id":"W1989256188","doi":"10.1021/jm030908a","title":"A New Generation of <i>N</i>-Aryl-<i>N</i>‘-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Organometallic Complex Synthesis and Catalysis","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Chemistry; Tubulin; Alkylation; Aryl; Cytotoxicity; Microtubule; Kinetics; Alkyl; Stereochemistry; Biochemistry; Organic chemistry; In vitro; Catalysis; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283469,0.0002797689,0.0002264952,0.0001350685,0.0001094551,0.0001907833,0.0003426862,0.000242307,0.0007449797],"category_scores_gemma":[0.000185268,0.0001137749,0.0001270404,0.0001094678,0.0001779695,0.0003352609,0.0001527937,0.0003421872,0.0002400908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448614,"about_ca_system_score_gemma":0.0002220439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004612652,"about_ca_topic_score_gemma":0.0009675315,"domain_scores_codex":[0.999952,0.000006884483,0.000004556106,0.00001303963,0.00001253504,0.00001102063],"domain_scores_gemma":[0.9999143,0.00001192363,0.00002924365,0.000007127337,0.00001723407,0.00002010627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008085369,0.00002522972,0.000181977,0.00009874435,0.000004589068,0.00006192768,0.00002730258,0.0001812231,0.9917888,0.0004110359,0.00007861069,0.00705968],"study_design_scores_gemma":[0.00002885605,0.0006239825,0.0006966795,0.000008824374,0.00001291404,0.0003217875,0.000009829132,0.0005080036,0.9888636,0.0000610362,0.008854547,0.000009928827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673332,0.01179095,0.01234937,0.0001339514,0.00006585794,0.00008023848,0.0002412849,0.0001645371,0.007840657],"genre_scores_gemma":[0.9731987,0.005652515,0.01558904,0.0001370688,0.00002872843,0.0001023314,0.0003220273,0.00003210223,0.004937427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007449797,"threshold_uncertainty_score":0.002492189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763999223954868,"score_gpt":0.2477539493051762,"score_spread":0.2301139570656275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}