{"id":"W1989256188","doi":"10.1021/jm030908a","title":"A New Generation of <i>N</i>-Aryl-<i>N</i>‘-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Organometallic Complex Synthesis and Catalysis","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"Centre Hospitalier Universitaire de Québec","keywords":"Chemistry; Tubulin; Alkylation; Aryl; Cytotoxicity; Microtubule; Kinetics; Alkyl; Stereochemistry; Biochemistry; Organic chemistry; In vitro; Catalysis; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005090436,0.0003219387,0.0007358096,0.00008362316,0.00007911533,0.00005136897,0.0002474371,0.000214803,0.005869304],"category_scores_gemma":[0.0009201494,0.0002795875,0.000234513,0.0002006716,0.0001503273,0.0002076884,0.00004959005,0.0003960851,0.000003422063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001039553,"about_ca_system_score_gemma":0.0002823136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003823593,"about_ca_topic_score_gemma":0.000005330839,"domain_scores_codex":[0.9978299,0.00003577646,0.0008438859,0.0003082725,0.0007221806,0.0002599789],"domain_scores_gemma":[0.9977673,0.0002991216,0.001011558,0.000327202,0.0002582068,0.0003366377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546262,0.0002090811,0.0008551351,0.0002701234,0.0002154734,0.00003307025,0.0002644951,0.00001047047,0.9783539,0.00002582991,0.0003587543,0.01924905],"study_design_scores_gemma":[0.0008716926,0.00009414268,0.0003879971,0.0003023304,0.0004827667,0.0008110918,0.0004244103,0.00007654035,0.9922046,0.0001758632,0.003924391,0.0002441665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889501,0.003691737,0.001239225,0.0005588544,0.00008239356,0.00005700664,0.00001717462,0.00001194495,0.005391593],"genre_scores_gemma":[0.9964316,0.0006977677,0.001250506,0.00004490396,0.0008114669,0.000003581244,0.000009405499,0.00003420241,0.0007165448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01900489,"threshold_uncertainty_score":0.9999656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763999223954868,"score_gpt":0.2477539493051762,"score_spread":0.2301139570656275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}