{"id":"W1989273697","doi":"10.1172/jci32103","title":"Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":835,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; School of Medicine, Stanford University; National Heart, Lung, and Blood Institute; School of Medicine, Oregon Health and Science University; National Cancer Institute; National Institutes of Health; National Center for Research Resources; Cancer Research Institute","keywords":"Adoptive cell transfer; Cytotoxic T cell; Biology; CD8; Effector; Immunology; T cell; Immunotherapy; Antigen; Cell biology; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001725846,0.0002271134,0.001126633,0.0002560324,0.00004406785,0.00001856154,0.0002303376,0.0003030563,0.000809481],"category_scores_gemma":[0.0006313491,0.0001856783,0.0007538074,0.0002393856,0.0006549574,0.0002962101,0.00003065015,0.001084697,0.00001666258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001748324,"about_ca_system_score_gemma":0.0008389903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001604713,"about_ca_topic_score_gemma":0.0000177708,"domain_scores_codex":[0.9955803,0.0007251053,0.002087693,0.0002908188,0.0009518571,0.0003641894],"domain_scores_gemma":[0.9961279,0.001946402,0.0005553173,0.0002761117,0.0005034066,0.0005908688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00207448,0.0007062325,0.04299587,0.0001910857,0.0001797018,0.0001829741,0.002678032,0.0006591702,0.9481181,0.000001243457,0.0006707695,0.001542364],"study_design_scores_gemma":[0.006026975,0.001728483,0.1556273,0.0003859039,0.0002122034,0.00002751195,0.0006181215,0.0007647097,0.8342811,0.00004513247,0.000133684,0.0001488735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969844,0.0005033549,0.00009851745,0.0005403641,0.0006630173,0.0005425514,0.00001911208,0.0000119522,0.0006367349],"genre_scores_gemma":[0.9943975,0.001109096,0.00309327,0.0003393505,0.0005977594,0.000004060553,0.00001929067,0.0000362221,0.0004034417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1138369,"threshold_uncertainty_score":0.8863249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07917265780015434,"score_gpt":0.3354791466112934,"score_spread":0.256306488811139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}