{"id":"W1989273697","doi":"10.1172/jci32103","title":"Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":835,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; School of Medicine, Stanford University; National Heart, Lung, and Blood Institute; School of Medicine, Oregon Health and Science University; National Cancer Institute; National Institutes of Health; National Center for Research Resources; Cancer Research Institute","keywords":"Adoptive cell transfer; Cytotoxic T cell; Biology; CD8; Effector; Immunology; T cell; Immunotherapy; Antigen; Cell biology; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004294899,0.0004230691,0.0003592048,0.0005848957,0.0005870761,0.0005938397,0.00039483,0.0004556172,0.001840298],"category_scores_gemma":[0.0004595205,0.0002799496,0.0001929685,0.0001983725,0.0005313896,0.0003074264,0.0003272974,0.001167595,0.0007054214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003130728,"about_ca_system_score_gemma":0.0002258171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005058554,"about_ca_topic_score_gemma":0.0006219504,"domain_scores_codex":[0.9997562,0.00004994841,0.00001605522,0.00007127335,0.00004563478,0.00006090161],"domain_scores_gemma":[0.9997604,0.00004220549,0.00004095963,0.0000869851,0.00002802855,0.00004131097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004774024,0.0002954846,0.001175887,0.00006777641,0.000018623,0.0003592419,0.0002815756,0.0001411997,0.9800284,0.0006529295,0.0003346977,0.01616691],"study_design_scores_gemma":[0.0006102233,0.00534559,0.01442624,0.0001452172,0.0001688309,0.006063745,0.0003326036,0.002870362,0.9279571,0.002845899,0.0392046,0.00002968747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784786,0.003640698,0.009754099,0.0001782774,0.00005068616,0.0002527926,0.0002813153,0.0004153759,0.006948174],"genre_scores_gemma":[0.9884824,0.001423943,0.004903432,0.000183343,0.00004914809,0.000278212,0.000578579,0.00009474689,0.004006334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840298,"threshold_uncertainty_score":0.006156385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07917265780015434,"score_gpt":0.3354791466112934,"score_spread":0.256306488811139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}