{"id":"W1989275863","doi":"10.1016/j.brainres.2004.09.031","title":"Nitric oxide mediates an LPS-induced depression of cytochrome P450 (CYP1A) activity in astrocytes","year":2004,"lang":"en","type":"article","venue":"Brain Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Nitric oxide; Nitric oxide synthase; Lipopolysaccharide; Proinflammatory cytokine; Cytochrome P450; Inflammation; Microglia; Downregulation and upregulation; Pharmacology; Chemistry; Neuroglia; Astrocyte; Endocrinology; Internal medicine; Biology; Biochemistry; Enzyme; Central nervous system; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237673,0.0001482924,0.0002044223,0.0008003199,0.0002055811,0.000077278,0.0004803126,0.0001011199,0.00006978999],"category_scores_gemma":[0.003447696,0.0001395454,0.00004743652,0.001328688,0.0001152626,0.0005082431,0.0001798055,0.0005346601,0.00007724018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000934535,"about_ca_system_score_gemma":0.0002354744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007134421,"about_ca_topic_score_gemma":0.00009967077,"domain_scores_codex":[0.9963102,0.00111571,0.0003090881,0.000604851,0.001164023,0.0004960982],"domain_scores_gemma":[0.9983532,0.0007649924,0.00009823228,0.0004718036,0.0001143056,0.0001974844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026726,0.0002178134,0.0001067241,0.0000198299,6.159643e-7,0.00005416733,0.0001236003,0.0003603129,0.9956473,0.001842378,0.00003355403,0.001490994],"study_design_scores_gemma":[0.0009595779,0.0002106525,0.02833686,0.00002647324,7.383122e-7,0.00001338215,0.00003414147,0.0009490761,0.9683615,0.0009680131,0.00002802842,0.0001115482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978446,0.00000643308,0.0002956137,0.000857497,0.00003624628,0.0005151364,0.000008014252,0.00007515818,0.000361284],"genre_scores_gemma":[0.9992248,0.00002143284,0.0002586513,0.0002088477,0.00005416947,0.000056933,0.000002685829,0.00002799933,0.0001444435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02823014,"threshold_uncertainty_score":0.5690495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.152008898396963,"score_gpt":0.397695180433499,"score_spread":0.2456862820365359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}