{"id":"W1989294696","doi":"10.1371/journal.pone.0085443","title":"Effects of Baseline CSF α-Synuclein on Regional Brain Atrophy Rates in Healthy Elders, Mild Cognitive Impairment and Alzheimer’s Disease","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Research and Development; National Institute on Aging; University of California, San Diego; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Vetenskapsrådet; Eisai; National Institute of Environmental Health Sciences; Northern California Institute for Research and Education; Danone; Pfizer; Biogen; BioClinica; Mayo Foundation for Medical Education and Research; F. Hoffmann-La Roche; Medpace; U.S. Public Health Service; Eli Lilly and Company; Bristol-Myers Squibb; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Synarc; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Brainstem; Medicine; Cerebrospinal fluid; Pathology; Internal medicine; Alzheimer's disease; Dementia with Lewy bodies; Hippocampus; Magnetic resonance imaging; Brain size; Psychology; Dementia; Cardiology; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001173402,0.0003575445,0.0004541399,0.0005975557,0.0003093825,0.0003724717,0.0001544778,0.0003350776,0.0007990623],"category_scores_gemma":[0.002986537,0.0001515311,0.0003611216,0.0002476417,0.0004126327,0.0002761416,0.0003310346,0.000205477,0.0001324311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116056,"about_ca_system_score_gemma":0.0002014274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003904625,"about_ca_topic_score_gemma":0.006116682,"domain_scores_codex":[0.9995418,0.0001580085,0.00004609137,0.0001123206,0.00008415562,0.00005769938],"domain_scores_gemma":[0.9980665,0.0007499113,0.0005558083,0.0001273953,0.000156453,0.0003440658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00651847,0.0002140613,0.9828523,0.00003889986,0.0003243707,0.0002962225,0.0002961518,0.0001668711,0.003905512,0.00001398993,0.00007573844,0.005297364],"study_design_scores_gemma":[0.00001017669,0.0003537654,0.9993365,0.000001450091,0.00002188443,0.00007195218,0.00003476647,0.00004321759,0.00009725376,0.000009286849,0.00001851875,0.000001225061],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996258,0.0001866635,0.00001532663,0.000006178524,0.000001808219,0.000002608653,0.00004676767,0.000001708827,0.0001131072],"genre_scores_gemma":[0.9997968,0.00003637269,0.00003351264,0.000008167097,0.00000282512,0.000003161267,0.00008175829,7.22138e-7,0.00003665084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003904625,"threshold_uncertainty_score":0.007763743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03747607700463139,"score_gpt":0.272691626119374,"score_spread":0.2352155491147426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}