{"id":"W1989308221","doi":"10.1093/emboj/20.23.6761","title":"Two distinct effects on neurotransmission in a temperature‐sensitive SNAP‐25 mutant","year":2001,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; National Institutes of Health; European Molecular Biology Organization; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; American Heart Association","keywords":"Biology; Mutant; SNARE complex; Neurotransmitter; Snap; Cell biology; Neurotransmission; Synaptic vesicle; Lipid bilayer fusion; Mutation; Vesicle; Biophysics; Receptor; Biochemistry; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614088,0.001266943,0.001079561,0.0005801404,0.0004419899,0.0005943496,0.001191713,0.001982815,0.003055871],"category_scores_gemma":[0.0005573066,0.0005092204,0.001119347,0.0002230594,0.001235269,0.0005933942,0.001099209,0.001867176,0.0007013201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006365554,"about_ca_system_score_gemma":0.0003581506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00159377,"about_ca_topic_score_gemma":0.001377847,"domain_scores_codex":[0.999597,0.00004938797,0.00009396453,0.00007581757,0.00009850055,0.00008525382],"domain_scores_gemma":[0.9990896,0.000210303,0.0001690124,0.000138122,0.00006213185,0.0003307944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002901886,0.00003300875,0.00006263536,0.00002501407,0.00001996164,0.0004442404,0.00001772,0.0000869246,0.9985593,0.0001552459,0.00002465418,0.0002810556],"study_design_scores_gemma":[0.00007348034,0.0003163895,0.003552195,0.00001469419,0.00006267797,0.001469997,0.00005911117,0.0009806704,0.9928191,0.0001829122,0.0004302757,0.00003842104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996454,0.0005356495,0.00128645,0.0001833826,0.0000885972,0.00002349048,0.000420206,0.0001440196,0.0008642884],"genre_scores_gemma":[0.9963142,0.0002818533,0.001404312,0.00009147121,0.00001103928,0.00004849154,0.0002205109,0.00009603817,0.001532151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003055871,"threshold_uncertainty_score":0.01022291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006580217048717802,"score_gpt":0.2392819451218625,"score_spread":0.2327017280731447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}