{"id":"W1989313702","doi":"10.1038/sj.bjc.6604830","title":"Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation","year":2008,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Women's College Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; Family history; Medicine; Cancer; Ovarian cancer; Oncology; Gynecology; Proband; Internal medicine; Incidence (geometry); Obstetrics; First-degree relatives; Mutation; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002374202,0.0002338208,0.0004951353,0.0001551616,0.0000794824,0.0000219392,0.0002646404,0.0001788662,0.0003238629],"category_scores_gemma":[0.00006724523,0.00021327,0.0001010514,0.0002640015,0.0003030883,0.00004501097,0.00003570075,0.0002402185,2.456826e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002116481,"about_ca_system_score_gemma":0.0067126,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0113262,"about_ca_topic_score_gemma":0.03568048,"domain_scores_codex":[0.9981475,0.00009062129,0.0006638337,0.0003556594,0.0003499055,0.0003924909],"domain_scores_gemma":[0.9975891,0.00005106604,0.0007975679,0.0001749384,0.001238088,0.0001492884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.05270546,0.0008638713,0.04849909,0.0005975069,0.002779905,0.001164508,0.01005503,0.02293959,0.06484934,0.000005259455,0.0784904,0.7170501],"study_design_scores_gemma":[0.01552282,0.001317688,0.9289159,0.00229618,0.0002346646,0.01247155,0.001867398,0.000363129,0.007976154,0.00004370813,0.02819041,0.0008003787],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815942,0.01472685,0.000660903,0.0004468629,0.0004336885,0.0005210596,0.001463924,0.000006289597,0.0001462028],"genre_scores_gemma":[0.9845759,0.009438404,0.001322561,0.0006404585,0.000709607,0.0006354516,0.0000129883,0.00007606335,0.002588589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8804168,"threshold_uncertainty_score":0.9989184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395123582956065,"score_gpt":0.2894584253315987,"score_spread":0.265507189502038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}