{"id":"W1989321356","doi":"10.1371/journal.pone.0002469","title":"A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"BioMarin Pharmaceutical","keywords":"Pharmacology; Drug delivery; Blood–brain barrier; Medicine; Transcytosis; Drug; Brain tumor; Glioma; Drug delivery to the brain; Pharmacokinetics; Conjugate; Chemistry; Receptor; Pathology; Internal medicine; Cancer research; Central nervous system; Endocytosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193957,0.0001390008,0.0002561658,0.00005177809,0.0004574525,0.00001289393,0.0002260472,0.00006010859,0.00005386203],"category_scores_gemma":[0.0002213672,0.00009400473,0.00009598425,0.0002163998,0.0004312849,0.00008242393,0.00005848864,0.0001429512,0.000003796801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001020332,"about_ca_system_score_gemma":0.00006274849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001248318,"about_ca_topic_score_gemma":0.000009096982,"domain_scores_codex":[0.9989123,0.00009738115,0.0002128913,0.0002557304,0.0003021841,0.0002194963],"domain_scores_gemma":[0.9986959,0.0007118427,0.00009140499,0.0003226888,0.0001239206,0.00005431984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001189667,0.0002505088,0.002698857,0.00004683872,0.0002458273,0.000004787294,0.002284599,0.000002450166,0.9864176,0.005350477,0.002332419,0.0002466972],"study_design_scores_gemma":[0.0008328767,0.0003054617,0.00180294,0.00001829397,0.000238885,0.00002418506,0.0001576212,0.0001242198,0.9828439,0.003572152,0.009889351,0.0001900724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933943,0.0004282546,0.0002774023,0.001729683,0.0001175558,0.0005098109,0.000135967,0.00005854498,0.003348554],"genre_scores_gemma":[0.9913452,0.0001220319,0.0002354765,0.005564319,0.0001165322,0.00008678312,0.000001923808,0.0000200394,0.002507727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007556932,"threshold_uncertainty_score":0.3833402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07991073930570258,"score_gpt":0.24133260671388,"score_spread":0.1614218674081774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}